Signal Peptide Database

Signal Peptide Database - Viruses

Entry Details

1294

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

P04580 (Created: 1987-08-13 Updated: 2008-11-25)

UniProtKB/Swiss-Prot Entry Name

ENV_HV1Z6

Protein Name

Envelope glycoprotein gp160

Gene

env

Organism Scientific

Human immunodeficiency virus type 1 (isolate Z6 group M subtype D)

Organism Common

HIV-1

Lineage

Viruses
  Retro-transcribing viruses
    Retroviridae
      Orthoretrovirinae
        Lentivirus
          Primate lentivirus group

Protein Length [aa]

855

Protein Mass [Da]

96971

Features

TypeDescriptionStatusStartEnd
signal peptide      by similarity   1   30
chain   Envelope glycoprotein gp160      31   855
chain   Surface protein   by similarity   31   510
chain   Transmembrane protein   by similarity   511   855
disulfide bond      by similarity   53   73
disulfide bond      by similarity   118   207
disulfide bond      by similarity   125   198
disulfide bond      by similarity   130   155
disulfide bond      by similarity   220   249
disulfide bond      by similarity   230   241
disulfide bond      by similarity   298   332
disulfide bond      by similarity   378   444
disulfide bond      by similarity   385   417
transmembrane region      potential   684   704
topological domain   Extracellular   potential   31   683
topological domain   Cytoplasmic   potential   705   855
region of interest   V1      130   154
region of interest   V2      155   198
region of interest   V3      298   331
region of interest   V4      385   417
region of interest   V5      459   470
region of interest   Fusion peptide   potential   511   531
region of interest   Immunosuppression   by similarity   575   591
region of interest   Involved in GalCer binding   by similarity   661   666
glycosylation site   N-linked (GlcNAc...)   potential   87   87
glycosylation site   N-linked (GlcNAc...)   potential   129   129
glycosylation site   N-linked (GlcNAc...)   potential   140   140
glycosylation site   N-linked (GlcNAc...)   potential   145   145
glycosylation site   N-linked (GlcNAc...)   potential   154   154
glycosylation site   N-linked (GlcNAc...)   potential   158   158
glycosylation site   N-linked (GlcNAc...)   potential   186   186
glycosylation site   N-linked (GlcNAc...)   potential   189   189
glycosylation site   N-linked (GlcNAc...)   potential   199   199
glycosylation site   N-linked (GlcNAc...)   potential   236   236
glycosylation site   N-linked (GlcNAc...)   potential   243   243
glycosylation site   N-linked (GlcNAc...)   potential   264   264
glycosylation site   N-linked (GlcNAc...)   potential   278   278
glycosylation site   N-linked (GlcNAc...)   potential   291   291
glycosylation site   N-linked (GlcNAc...)   potential   297   297
glycosylation site   N-linked (GlcNAc...)   potential   333   333
glycosylation site   N-linked (GlcNAc...)   potential   340   340
glycosylation site   N-linked (GlcNAc...)   potential   355   355
glycosylation site   N-linked (GlcNAc...)   potential   386   386
glycosylation site   N-linked (GlcNAc...)   potential   392   392
glycosylation site   N-linked (GlcNAc...)   potential   398   398
glycosylation site   N-linked (GlcNAc...)   potential   404   404
glycosylation site   N-linked (GlcNAc...)   potential   443   443
glycosylation site   N-linked (GlcNAc...)   potential   447   447
glycosylation site   N-linked (GlcNAc...)   potential   460   460
glycosylation site   N-linked (GlcNAc...)   potential   461   461
glycosylation site   N-linked (GlcNAc...)   potential   464   464
glycosylation site   N-linked (GlcNAc...)   potential   610   610
glycosylation site   N-linked (GlcNAc...)   potential   615   615
glycosylation site   N-linked (GlcNAc...)   potential   624   624
glycosylation site   N-linked (GlcNAc...)   potential   636   636
glycosylation site   N-linked (GlcNAc...)   potential   673   673
site   Cleavage; by host furin   by similarity   510   511
short sequence motif   YXXL motif; contains endocytosis signal   by similarity   711   714
lipid moiety-binding region   S-palmitoyl cysteine; by host   by similarity   763   763
turn         664   667
coiled-coil region      potential   541   591
coiled-coil region      potential   632   666

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MRAREIERNCPNLWKWGIMLLGILMICSAA

Sequence

MRAREIERNCPNLWKWGIMLLGILMICSAADNLWVTVYYGVPVWKEATTT
LFCASDAKSYKTEAHNIWATHACVPTDPNPQEIELENVTENFNMWRNNMV
EQIHEDIISLWDQSLKPCVKLTPLCVTLNCTDESDEWMGNVTGKNVTEDI
RMKNCSFNITTVVRDKTKQVHALFYRLDIVPIDNDNSTNSTNYRLINCNT
SAITQACPKVSFEPIPIHYCAPAGFAILKCRDKRFNGTGPCTNVSTVQCT
HGIRPVVSTQLLLNGSLAEEEIIIRSENLTNNAKIIIVQLNESVAINCTR
PYKNTRQSTPIGLGQALYTTRGRTKIIGQAHCNISKEDWNKTLQRVAIKL
GNLLNKTTIIFKPSSGGDAEITTHSFNCGGEFFYCNTSGLFNSTWNINNS
EGANSTESDNKLITLQCRIKQIINMWQGVGKAMYAPPIEGQINCSSNITG
LLLTRDGGTNNSSNETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTKA
KRRVVEREKRAIGLGAMFLGFLGAAGSTMGAASVTLTVQARQLMSGIVQQ
QNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQQLLGIWGCSGK
LICTTTVPWNSSWSNRSLNDIWQNMTWMEWEREIDNYTGLIYRLIEESQT
QQEKNEQELLELDKWASLWNWFNITQWLWYIKIFIMIVGGLIGLRIVFAV
LSLVNRVRQGYSPLSFQTLLPAPREPDRPEGIEEEGGERGRDRSIRLVNG
FSALIWDDLRNLCLFSYHRLRDLILIAARIVELLGRRGWEALKYLWNLLQ
YWSRELRNSASSLLDTIAIAVAEGTDRVIEIVRRTYRAVLNVPTRIRQGL
ERLLL

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website