Signal Peptide Database

Signal Peptide Database - Viruses

Entry Details

2296

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

O70902 (Created: 2006-06-27 Updated: 2008-11-25)

UniProtKB/Swiss-Prot Entry Name

ENV_HV190

Protein Name

Envelope glycoprotein gp160

Gene

env

Organism Scientific

Human immunodeficiency virus type 1 (isolate 90CF056 group M subtype H)

Organism Common

HIV-1

Lineage

Viruses
  Retro-transcribing viruses
    Retroviridae
      Orthoretrovirinae
        Lentivirus
          Primate lentivirus group

Protein Length [aa]

845

Protein Mass [Da]

95827

Features

TypeDescriptionStatusStartEnd
signal peptide      by similarity   1   28
chain   Envelope glycoprotein gp160   by similarity   29   845
chain   Surface protein   by similarity   29   500
chain   Transmembrane protein   by similarity   501   845
disulfide bond      by similarity   50   70
disulfide bond      by similarity   115   198
disulfide bond      by similarity   122   189
disulfide bond      by similarity   127   150
disulfide bond      by similarity   211   240
disulfide bond      by similarity   221   232
disulfide bond      by similarity   289   323
disulfide bond      by similarity   369   434
disulfide bond      by similarity   376   407
transmembrane region      potential   674   694
topological domain   Extracellular   potential   29   673
topological domain   Cytoplasmic   potential   695   845
region of interest   V1      127   149
region of interest   V2      150   189
region of interest   V3      289   322
region of interest   V4      376   407
region of interest   V5      450   460
region of interest   Fusion peptide   potential   501   521
region of interest   Immunosuppression   by similarity   565   581
region of interest   Involved in GalCer binding   by similarity   651   656
glycosylation site   N-linked (GlcNAc...)   potential   84   84
glycosylation site   N-linked (GlcNAc...)   potential   126   126
glycosylation site   N-linked (GlcNAc...)   potential   132   132
glycosylation site   N-linked (GlcNAc...)   potential   133   133
glycosylation site   N-linked (GlcNAc...)   potential   136   136
glycosylation site   N-linked (GlcNAc...)   potential   149   149
glycosylation site   N-linked (GlcNAc...)   potential   153   153
glycosylation site   N-linked (GlcNAc...)   potential   179   179
glycosylation site   N-linked (GlcNAc...)   potential   180   180
glycosylation site   N-linked (GlcNAc...)   potential   190   190
glycosylation site   N-linked (GlcNAc...)   potential   223   223
glycosylation site   N-linked (GlcNAc...)   potential   227   227
glycosylation site   N-linked (GlcNAc...)   potential   234   234
glycosylation site   N-linked (GlcNAc...)   potential   255   255
glycosylation site   N-linked (GlcNAc...)   potential   269   269
glycosylation site   N-linked (GlcNAc...)   potential   286   286
glycosylation site   N-linked (GlcNAc...)   potential   294   294
glycosylation site   N-linked (GlcNAc...)   potential   324   324
glycosylation site   N-linked (GlcNAc...)   potential   331   331
glycosylation site   N-linked (GlcNAc...)   potential   347   347
glycosylation site   N-linked (GlcNAc...)   potential   377   377
glycosylation site   N-linked (GlcNAc...)   potential   383   383
glycosylation site   N-linked (GlcNAc...)   potential   391   391
glycosylation site   N-linked (GlcNAc...)   potential   395   395
glycosylation site   N-linked (GlcNAc...)   potential   402   402
glycosylation site   N-linked (GlcNAc...)   potential   437   437
glycosylation site   N-linked (GlcNAc...)   potential   449   449
glycosylation site   N-linked (GlcNAc...)   potential   454   454
glycosylation site   N-linked (GlcNAc...)   potential   600   600
glycosylation site   N-linked (GlcNAc...)   potential   605   605
glycosylation site   N-linked (GlcNAc...)   potential   614   614
glycosylation site   N-linked (GlcNAc...)   potential   626   626
site   Cleavage; by host furin   by similarity   500   501
short sequence motif   YXXL motif; contains endocytosis signal   by similarity   701   704
coiled-coil region      potential   531   581
coiled-coil region      potential   622   656

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

METQRNYPSLWRWGTLILGMLLICSAAQ

Sequence

METQRNYPSLWRWGTLILGMLLICSAAQNLWVTVYYGVPVWKEAKTTLFC
ASDAKAYETEKHNVWATHACVPTDPNPQEMVMENVTESFNMWENNMVEQM
HTDIISLWDQSLKPCVKLTPLCVTLNCTNVRNNTSNSTSSMEAGGELTNC
SFNVTTVLRDKQQKVHALFYRLDVVPIDNNSTQYRLINCNTSVITQACPK
VSFEPIPIHYCAPAGFAILKCNNKTFNGTGLCTNVSTVQCTHGIRPVVST
QLLLNGSLAEEQIIIRTKNISDNTKNIIVQLKTPVNITCTRPNNNTRTSI
HLGPGRAFYATGDIIGDIRQAHCNISRTDWNKTLHQVVTQLGIHLNNRTI
SFKPNSGGDMEVRTHSFNCRGEFFYCNTSGLFNSSWEMHTNYTSNDTKGN
ENITLPCRIKQIVNMWQRVGRAMYAPPIQGNIMCVSNITGLILTIDEGNA
SAENYTFRPGGGDMRDNWRSELYKYKVVKIEPLGIAPTKTRRRVVEREKR
AVGMGASFLGFLGAAGSTMGAASITLTVQARQLLSGIVQQQSNLLRAIQA
RQHMLQLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICTTNVPWN
SSWSNKSQSEIWDNMTWMEWDKQISNYTEEIYRLLEVSQTQQEKNEQDLL
ALDKWASLWTWFDISHWLWYIKIFIMIVGGLIGLRIIFAVLSIVNRVRQG
YSPLSFQTLVPNPRGPDRPEGTEEGGGEQDRDRSVRLVNGFLPVVWDDLR
SLSLFSYRLLRDLLLIVVRTVELLGRRGREALKYLWNLLQYWGQELKNSA
IDLLNTTAIAVAEGTDGIIVIVQRAWRAILHIPRRIRQGFERSLL

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website