Signal Peptide Database

Signal Peptide Database - Viruses

Entry Details

2297

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

P20888 (Created: 1991-02-01 Updated: 2008-11-25)

UniProtKB/Swiss-Prot Entry Name

ENV_HV1OY

Protein Name

Envelope glycoprotein gp160

Gene

env

Organism Scientific

Human immunodeficiency virus type 1 (isolate OYI group M subtype B)

Organism Common

HIV-1

Lineage

Viruses
  Retro-transcribing viruses
    Retroviridae
      Orthoretrovirinae
        Lentivirus
          Primate lentivirus group

Protein Length [aa]

855

Protein Mass [Da]

97476

Features

TypeDescriptionStatusStartEnd
signal peptide      by similarity   1   31
chain   Envelope glycoprotein gp160      32   855
chain   Surface protein   by similarity   32   509
chain   Transmembrane protein   by similarity   510   855
disulfide bond      by similarity   53   73
disulfide bond      by similarity   118   210
disulfide bond      by similarity   125   201
disulfide bond      by similarity   130   162
disulfide bond      by similarity   223   252
disulfide bond      by similarity   233   244
disulfide bond      by similarity   301   335
disulfide bond      by similarity   381   442
disulfide bond      by similarity   388   415
transmembrane region      potential   684   704
topological domain   Extracellular   potential   32   683
topological domain   Cytoplasmic   potential   705   855
region of interest   V1      130   161
region of interest   V2      162   201
region of interest   V3      301   334
region of interest   V4      388   415
region of interest   V5      458   469
region of interest   Fusion peptide   potential   510   530
region of interest   Immunosuppression   by similarity   575   591
region of interest   Involved in GalCer binding   by similarity   661   666
glycosylation site   N-linked (GlcNAc...)   potential   87   87
glycosylation site   N-linked (GlcNAc...)   potential   134   134
glycosylation site   N-linked (GlcNAc...)   potential   142   142
glycosylation site   N-linked (GlcNAc...)   potential   145   145
glycosylation site   N-linked (GlcNAc...)   potential   161   161
glycosylation site   N-linked (GlcNAc...)   potential   165   165
glycosylation site   N-linked (GlcNAc...)   potential   192   192
glycosylation site   N-linked (GlcNAc...)   potential   202   202
glycosylation site   N-linked (GlcNAc...)   potential   239   239
glycosylation site   N-linked (GlcNAc...)   potential   246   246
glycosylation site   N-linked (GlcNAc...)   potential   267   267
glycosylation site   N-linked (GlcNAc...)   potential   281   281
glycosylation site   N-linked (GlcNAc...)   potential   294   294
glycosylation site   N-linked (GlcNAc...)   potential   300   300
glycosylation site   N-linked (GlcNAc...)   potential   306   306
glycosylation site   N-linked (GlcNAc...)   potential   336   336
glycosylation site   N-linked (GlcNAc...)   potential   359   359
glycosylation site   N-linked (GlcNAc...)   potential   389   389
glycosylation site   N-linked (GlcNAc...)   potential   395   395
glycosylation site   N-linked (GlcNAc...)   potential   399   399
glycosylation site   N-linked (GlcNAc...)   potential   405   405
glycosylation site   N-linked (GlcNAc...)   potential   458   458
glycosylation site   N-linked (GlcNAc...)   potential   610   610
glycosylation site   N-linked (GlcNAc...)   potential   615   615
glycosylation site   N-linked (GlcNAc...)   potential   624   624
glycosylation site   N-linked (GlcNAc...)   potential   636   636
site   Cleavage; by host furin   by similarity   509   510
short sequence motif   YXXL motif; contains endocytosis signal   by similarity   711   714
lipid moiety-binding region   S-palmitoyl cysteine; by host   by similarity   763   763
coiled-coil region      potential   541   591
coiled-coil region      potential   632   666

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MTARGTRKNYQRLWRWGTMLLGMLMICSAAE

Sequence

MTARGTRKNYQRLWRWGTMLLGMLMICSAAENLWVTVYYGVPVWKEATTT
LFCASDARAYATEVHNVWATHACVPTDPNPQEVVLGNVTENFDMWKNNMV
EQMQEDIISLWDQSLKPCVKLTPLCVTLDCTDVNTTSSSLRNATNTTSSS
WETMEKGELKNCSFNTTTSIRDKMQEQYALFYKLDVLPIDKNDTKFRLIH
CNTSTITQACPKISFEPIPMHYCTPAGFAILKCNDKKFNGTGPCTNVSTV
QCTHGIKPVVSTQLLLNGSLAEEEVIIRSSNFTNNAKIIIVQLNKSVEIN
CTRPNNNTRNRISIGPGRAFHTTKQIIGDIRQAHCNLSRATWEKTLEQIA
TKLRKQFRNKTIAFDRSSGGDPEIVMHSFNCGGEFFYCNTSQLFNSTWND
TTRANSTEVTITLPCRIKQIVNMWQEVGKAMYAPPISGQIRCSSKITGLL
LTRDGGKNTTNGIEIFRPAGGDMRDNWRSELYKYKVVKIEPLGVAPTKAR
RRVVQREKRAVGMLGAMFLGFLGAAGSTMGARSMTLTVQARQLLSGIVQQ
QNNLLRAIEAQQHLLQLTVWGIKQLQARVLAVERYLKDQQLLGIWGCSGK
LICTTTVPWNASWSNKSLNEIWDNMTWMQWEREIDNYTHLIYTLIEESQN
QQEKNEQELLELDKWAGLWSWFSITNWLWYIRIFIIIVGGLVGLRIVFAV
LSIVNRVRQGYSPLSFQTRLPTQRGPDRPEGIEEEGGERDRDRSGRLVDG
FLALIWDDLRSLCLFSYHRLRDLILIVARIVELLGRRGWEVLKYWWNLLQ
YWSQELKNSVISLLNATAIAVAEGTDRVIEIVQRAYRAFLNIPRRIRQGL
ERALL

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website