Signal Peptide Database

Signal Peptide Database - Mammalia

Entry Details

1649

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

O43612 (Created: 2000-05-30 Updated: 2008-12-16)

UniProtKB/Swiss-Prot Entry Name

OREX_HUMAN

Protein Name

Orexin

Gene

HCRT

Organism Scientific

Homo sapiens

Organism Common

Human

Lineage

Eukaryota
  Metazoa
    Chordata
      Craniata
        Vertebrata
          Euteleostomi
            Mammalia
              Eutheria
                Euarchontoglires
                  Primates
                    Haplorrhini
                      Catarrhini
                        Hominidae
                          Homo

Protein Length [aa]

131

Protein Mass [Da]

13363

Features

TypeDescriptionStatusStartEnd
signal peptide      by similarity   1   33
disulfide bond         39   45
disulfide bond         40   47
modified residue   Pyrrolidone carboxylic acid   by similarity   34   34
modified residue   Leucine amide   by similarity   66   66
modified residue   Methionine amide   by similarity   97   97
sequence variant   (in narcolepsy; early-onset; impaired trafficking, processing)      0   0
strand         43   45
helix         47   54
helix         58   64
helix         76   86
helix         91   95
propeptide         98   131
peptide   Orexin-A. /FTId=PRO_0000020261      34   66
peptide   Orexin-B. /FTId=PRO_0000020262      70   97
turn         40   42
turn         87   89

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MNLPSTKVSWAAVTLLLLLLLLPPALLSSGAAA

Sequence

MNLPSTKVSWAAVTLLLLLLLLPPALLSSGAAAQPLPDCCRQKTCSCRLY
ELLHGAGNHAAGILTLGKRRSGPPGLQGRLQRLLQASGNHAAGILTMGRR
AGAEPAPRPCLGRRCSAPAAASVAPGGQSGI

Original

MNLPSTKVSWAAVTLLLLLLLLPPALLSSGAAAQPLPDCCRQKTCSCRLY
ELLHGAGNHAAGILTLGKRRSGPPGLQGRLQRLLQASGNHAAGILTMGRR
AGAEPAPRPCLGRRCSAPAAASVAPGGQSGI

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website