Signal Peptide Database

Signal Peptide Database - Mammalia

Entry Details

29717

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

Q9UEF7 (Created: 2005-10-11 Updated: 2009-01-20)

UniProtKB/Swiss-Prot Entry Name

KLOT_HUMAN

Protein Name

Klotho

Gene

Organism Scientific

Homo sapiens

Organism Common

Human

Lineage

Eukaryota
  Metazoa
    Chordata
      Craniata
        Vertebrata
          Euteleostomi
            Mammalia
              Eutheria
                Euarchontoglires
                  Primates
                    Haplorrhini
                      Catarrhini
                        Hominidae
                          Homo

Protein Length [aa]

1012

Protein Mass [Da]

116181

Features

TypeDescriptionStatusStartEnd
signal peptide      potential   1   33
chain   Klotho      34   1012
chain   Klotho peptide   by similarity   34   0
transmembrane region      potential   982   1002
topological domain   Extracellular   potential   34   981
topological domain   Cytoplasmic   potential   1003   1012
region of interest   Glycosyl hydrolase-1 1      57   506
region of interest   Glycosyl hydrolase-1 2      515   953
modified residue   Phosphotyrosine   by similarity   497   497
glycosylation site   N-linked (GlcNAc...)   potential   106   106
glycosylation site   N-linked (GlcNAc...)   potential   159   159
glycosylation site   N-linked (GlcNAc...)   potential   283   283
glycosylation site   N-linked (GlcNAc...)   potential   344   344
glycosylation site   N-linked (GlcNAc...)   potential   607   607
glycosylation site   N-linked (GlcNAc...)   potential   612   612
glycosylation site   N-linked (GlcNAc...)   potential   694   694
sequence variant   (in dbSNP:rs3752472)      0   0
sequence variant   (in allele KL-VS; associated with V-352; dbSNP:rs9527025)      0   0
sequence variant   (in allele KL-VS; associated with S-370; dbSNP:rs9536314)      0   0
sequence variant   (in dbSNP:rs1052019)      0   0
sequence variant   (in dbSNP:rs1052018)      0   0
sequence variant   (in a colorectal cancer sample; somatic mutation)      0   0
splice variant   (in isoform 2)      0   0
splice variant   (in isoform 2)      550   1012

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MPASAPPRRPRPPPPSLSLLLVLLGLGGRRLRA

Sequence

MPASAPPRRPRPPPPSLSLLLVLLGLGGRRLRAEPGDGAQTWARFSRPPA
PEAAGLFQGTFPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAP
PGDSRNASLPLGAPSPLQPATGDVASDSYNNVFRDTEALRELGVTHYRFS
ISWARVLPNGSAGVPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRL
QDAYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNPYVVAWHGYAT
GRLAPGIRGSPRLGYLVAHNLLLAHAKVWHLYNTSFRPTQGGQVSIALSS
HWINPRRMTDHSIKECQKSLDFVLGWFAKPVFIDGDYPESMKNNLSSILP
DFTESEKKFIKGTADFFALCFGPTLSFQLLDPHMKFRQLESPNLRQLLSW
IDLEFNHPQIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETLKAIKLDGV
DVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKSSALFYQKL
IEKNGFPPLPENQPLEGTFPCDFAWGVVDNYIQVDTTLSQFTDLNVYLWD
VHHSKRLIKVDGVVTKKRKSYCVDFAAIQPQIALLQEMHVTHFRFSLDWA
LILPLGNQSQVNHTILQYYRCMASELVRVNITPVVALWQPMAPNQGLPRL
LARQGAWENPYTALAFAEYARLCFQELGHHVKLWITMNEPYTRNMTYSAG
HNLLKAHALAWHVYNEKFRHAQNGKISIALQADWIEPACPFSQKDKEVAE
RVLEFDIGWLAEPIFGSGDYPWVMRDWLNQRNNFLLPYFTEDEKKLIQGT
FDFLALSHYTTILVDSEKEDPIKYNDYLEVQEMTDITWLNSPSQVAVVPW
GLRKVLNWLKFKYGDLPMYIISNGIDDGLHAEDDQLRVYYMQNYINEALK
AHILDGINLCGYFAYSFNDRTAPRFGLYRYAADQFEPKASMKHYRKIIDS
NGFPGPETLERFCPEEFTVCTECSFFHTRKSLLAFIAFLFFASIISLSLI
FYYSKKGRRSYK

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website