Signal Peptide Database

Signal Peptide Database - Mammalia

Entry Details

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

P04114 (Created: 1986-11-01 Updated: 2009-01-20)

UniProtKB/Swiss-Prot Entry Name

APOB_HUMAN

Protein Name

Apolipoprotein B-100

Gene

APOB

Organism Scientific

Homo sapiens

Organism Common

Human

Lineage

Eukaryota
  Metazoa
    Chordata
      Craniata
        Vertebrata
          Euteleostomi
            Mammalia
              Eutheria
                Euarchontoglires
                  Primates
                    Haplorrhini
                      Catarrhini
                        Hominidae
                          Homo

Protein Length [aa]

4563

Protein Mass [Da]

515563

Features

TypeDescriptionStatusStartEnd
signal peptide         1   27
chain   Apolipoprotein B-100      28   4563
chain   Apolipoprotein B-48      28   2179
disulfide bond         39   88
disulfide bond         78   97
disulfide bond         186   212
disulfide bond         245   261
disulfide bond         385   390
disulfide bond         478   513
disulfide bond         966   976
disulfide bond         3194   3324
domain   Vitellogenin      46   672
region of interest   Heparin-binding      32   126
region of interest   Heparin-binding      232   306
region of interest   Heparin-binding      902   959
region of interest   Heparin-binding      2043   2178
region of interest   Heparin-binding      3161   3236
region of interest   Basic (possible receptor binding region)      3174   3184
region of interest   LDL receptor binding      3373   3393
region of interest   Heparin-binding      3383   3516
region of interest   Basic (possible receptor binding region)      3386   3394
modified residue   Phosphoserine      928   928
modified residue   Phosphoserine      4507   4507
glycosylation site   N-linked (GlcNAc...)   potential   34   34
glycosylation site   N-linked (GlcNAc...)   potential   185   185
glycosylation site   N-linked (GlcNAc...)   potential   983   983
glycosylation site   N-linked (GlcNAc...)   potential   1368   1368
glycosylation site   N-linked (GlcNAc...)   potential   1377   1377
glycosylation site   N-linked (GlcNAc...)      1523   1523
glycosylation site   N-linked (GlcNAc...)   potential   2239   2239
glycosylation site   N-linked (GlcNAc...)   potential   2560   2560
glycosylation site   N-linked (GlcNAc...)   potential   2779   2779
glycosylation site   N-linked (GlcNAc...)      2982   2982
glycosylation site   N-linked (GlcNAc...)   potential   3101   3101
glycosylation site   N-linked (GlcNAc...)   potential   3224   3224
glycosylation site   N-linked (GlcNAc...)   potential   3336   3336
glycosylation site   N-linked (GlcNAc...)      3358   3358
glycosylation site   N-linked (GlcNAc...)   potential   3411   3411
glycosylation site   N-linked (GlcNAc...)      3465   3465
glycosylation site   N-linked (GlcNAc...)      3895   3895
glycosylation site   N-linked (GlcNAc...)   potential   4237   4237
glycosylation site   N-linked (GlcNAc...)   potential   4431   4431
sequence variant   (in FDB; dbSNP:rs12713559)      0   0
sequence variant   (in FDB; dbSNP:rs5742904)      0   0
sequence variant   (in dbSNP:rs1042023)      0   0
sequence variant         0   0
sequence variant         0   0
sequence variant   (in dbSNP:rs12720855)      0   0
sequence variant   (in dbSNP:rs12720854)      0   0
sequence variant   (in dbSNP:rs12720848)      0   0
sequence variant   (in dbSNP:rs1801694)      0   0
sequence variant   (in dbSNP:rs2163204)      0   0
sequence variant   (in dbSNP:rs676210)      0   0
sequence variant   (in dbSNP:rs1801701)      0   0
sequence variant   (in dbSNP:rs1042025)      0   0
sequence variant   (in dbSNP:rs12713540)      0   0
sequence variant   (in dbSNP:rs12713450)      0   0
sequence variant   (in dbSNP:rs1801695)      0   0
sequence variant   (in dbSNP:rs12720843)      0   0
sequence variant   (in dbSNP:rs1042034)      0   0
sequence variant   (in dbSNP:rs1801702)      0   0
sequence variant   (in dbSNP:rs1042031)      0   0
sequence variant   (in dbSNP:rs1801703)      0   0
sequence variant   (in dbSNP:rs1126468)      0   0
sequence variant   (in dbSNP:rs1042027)      0   0
sequence variant   (in dbSNP:rs1801698)      0   0
sequence variant         0   0
sequence variant   (in dbSNP:rs1042013)      0   0
sequence variant   (in dbSNP:rs1801696)      0   0
sequence variant   (in a colorectal cancer sample; somatic mutation)      0   0
sequence variant   (in dbSNP:rs12714192)      0   0
sequence variant   (in dbSNP:rs1800476)      0   0
sequence variant   (in dbSNP:rs12691202)      0   0
sequence variant   (in dbSNP:rs679899)      0   0
sequence variant   (in dbSNP:rs12714214)      0   0
sequence variant   (in FHBL; reduced protein secretion)      0   0
sequence variant   (in dbSNP:rs12714225)      0   0
sequence variant   (in dbSNP:rs1126419)      0   0
sequence variant   (in dbSNP:rs6752026)      0   0
sequence variant   (in dbSNP:rs9282603)      0   0
sequence variant   (in dbSNP:rs1367117)      0   0
sequence variant   (in dbSNP:rs12714097)      0   0
sequence variant   (in dbSNP:rs12720801)      0   0
sequence variant   (in dbSNP:rs12713675)      0   0
sequence variant   (in dbSNP:rs1041971)      0   0
sequence variant   (in dbSNP:rs12713681)      0   0
sequence variant   (in dbSNP:rs1041960)      0   0
sequence variant   (in dbSNP:rs533617)      0   0
sequence variant   (in dbSNP:rs1801699)      0   0
sequence variant   (in dbSNP:rs1801697)      0   0
sequence variant   (in dbSNP:rs13306187)      0   0
sequence variant   (in dbSNP:rs1041956)      0   0
sequence variant   (in dbSNP:rs12713843)      0   0
sequence variant   (in dbSNP:rs12713844)      0   0
lipid moiety-binding region   S-palmitoyl cysteine      1112   1112
mutagenesis site   Impairs protein secretion      0   0
mutagenesis site   Does not affect protein secretion      0   0
mutagenesis site   Impairs protein secretion      0   0
mutagenesis site   Does not affect protein secretion      0   0

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MDPPRPALLALLALPALLLLLLAGARA

Sequence

MDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLR
KYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLK
EVYGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEP
TYILNIKRGIISALLVPPETEEAKQVLFLDTVYGNCSTHFTVKTRKGNVA
TEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLISSSQSCQYTLD
AKRKHVAEAICKEQHLFLPFSYNNKYGMVAQVTQTLKLEDTPKINSRFFG
EGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKKLTISEQNIQRANLFNK
LVTELRGLSDEAVTSLLPQLIEVSSPITLQALVQCGQPQCSTHILQWLKR
VHANPLLIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHAVN
NYHKTNPTGTQELLDIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTME
QLTPELKSSILKCVQSTKPSLMIQKAAIQALRKMEPKDKDQEVLLQTFLD
DASPGDKRLAAYLMLMRSPSQADINKIVQILPWEQNEQVKNFVASHIANI
LNSEELDIQDLKKLVKEALKESQLPTVMDFRKFSRNYQLYKSVSLPSLDP
ASAKIEGNLIFDPNNYLPKESMLKTTLTAFGFASADLIEIGLEGKGFEPT
LEALFGKQGFFPDSVNKALYWVNGQVPDGVSKVLVDHFGYTKDDKHEQDM
VNGIMLSVEKLIKDLKSKEVPEARAYLRILGEELGFASLHDLQLLGKLLL
MGARTLQGIPQMIGEVIRKGSKNDFFLHYIFMENAFELPTGAGLQLQISS
SGVIAPGAKAGVKLEVANMQAELVAKPSVSVEFVTNMGIIIPDFARSGVQ
MNTNFFHESGLEAHVALKAGKLKFIIPSPKRPVKLLSGGNTLHLVSTTKT
EVIPPLIENRQSWSVCKQVFPGLNYCTSGAYSNASSTDSASYYPLTGDTR
LELELRPTGEIEQYSVSATYELQREDRALVDTLKFVTQAEGAKQTEATMT
FKYNRQSMTLSSEVQIPDFDVDLGTILRVNDESTEGKTSYRLTLDIQNKK
ITEVALMGHLSCDTKEERKIKGVISIPRLQAEARSEILAHWSPAKLLLQM
DSSATAYGSTVSKRVAWHYDEEKIEFEWNTGTNVDTKKMTSNFPVDLSDY
PKSLHMYANRLLDHRVPETDMTFRHVGSKLIVAMSSWLQKASGSLPYTQT
LQDHLNSLKEFNLQNMGLPDFHIPENLFLKSDGRVKYTLNKNSLKIEIPL
PFGGKSSRDLKMLETVRTPALHFKSVGFHLPSREFQVPTFTIPKLYQLQV
PLLGVLDLSTNVYSNLYNWSASYSGGNTSTDHFSLRARYHMKADSVVDLL
SYNVQGSGETTYDHKNTFTLSCDGSLRHKFLDSNIKFSHVEKLGNNPVSK
GLLIFDASSSWGPQMSASVHLDSKKKQHLFVKEVKIDGQFRVSSFYAKGT
YGLSCQRDPNTGRLNGESNLRFNSSYLQGTNQITGRYEDGTLSLTSTSDL
QSGIIKNTASLKYENYELTLKSDTNGKYKNFATSNKMDMTFSKQNALLRS
EYQADYESLRFFSLLSGSLNSHGLELNADILGTDKINSGAHKATLRIGQD
GISTSATTNLKCSLLVLENELNAELGLSGASMKLTTNGRFREHNAKFSLD
GKAALTELSLGSAYQAMILGVDSKNIFNFKVSQEGLKLSNDMMGSYAEMK
FDHTNSLNIAGLSLDFSSKLDNIYSSDKFYKQTVNLQLQPYSLVTTLNSD
LKYNALDLTNNGKLRLEPLKLHVAGNLKGAYQNNEIKHIYAISSAALSAS
YKADTVAKVQGVEFSHRLNTDIAGLASAIDMSTNYNSDSLHFSNVFRSVM
APFTMTIDAHTNGNGKLALWGEHTGQLYSKFLLKAEPLAFTFSHDYKGST
SHHLVSRKSISAALEHKVSALLTPAEQTGTWKLKTQFNNNEYSQDLDAYN
TKDKIGVELTGRTLADLTLLDSPIKVPLLLSEPINIIDALEMRDAVEKPQ
EFTIVAFVKYDKNQDVHSINLPFFETLQEYFERNRQTIIVVVENVQRNLK
HINIDQFVRKYRAALGKLPQQANDYLNSFNWERQVSHAKEKLTALTKKYR
ITENDIQIALDDAKINFNEKLSQLQTYMIQFDQYIKDSYDLHDLKIAIAN
IIDEIIEKLKSLDEHYHIRVNLVKTIHDLHLFIENIDFNKSGSSTASWIQ
NVDTKYQIRIQIQEKLQQLKRHIQNIDIQHLAGKLKQHIEAIDVRVLLDQ
LGTTISFERINDVLEHVKHFVINLIGDFEVAEKINAFRAKVHELIERYEV
DQQIQVLMDKLVELTHQYKLKETIQKLSNVLQQVKIKDYFEKLVGFIDDA
VKKLNELSFKTFIEDVNKFLDMLIKKLKSFDYHQFVDETNDKIREVTQRL
NGEIQALELPQKAEALKLFLEETKATVAVYLESLQDTKITLIINWLQEAL
SSASLAHMKAKFRETLEDTRDRMYQMDIQQELQRYLSLVGQVYSTLVTYI
SDWWTLAAKNLTDFAEQYSIQDWAKRMKALVEQGFTVPEIKTILGTMPAF
EVSLQALQKATFQTPDFIVPLTDLRIPSVQINFKDLKNIKIPSRFSTPEF
TILNTFHIPSFTIDFVEMKVKIIRTIDQMQNSELQWPVPDIYLRDLKVED
IPLARITLPDFRLPEIAIPEFIIPTLNLNDFQVPDLHIPEFQLPHISHTI
EVPTFGKLYSILKIQSPLFTLDANADIGNGTTSANEAGIAASITAKGESK
LEVLNFDFQANAQLSNPKINPLALKESVKFSSKYLRTEHGSEMLFFGNAI
EGKSNTVASLHTEKNTLELSNGVIVKINNQLTLDSNTKYFHKLNIPKLDF
SSQADLRNEIKTLLKAGHIAWTSSGKGSWKWACPRFSDEGTHESQISFTI
EGPLTSFGLSNKINSKHLRVNQNLVYESGSLNFSKLEIQSQVDSQHVGHS
VLTAKGMALFGEGKAEFTGRHDAHLNGKVIGTLKNSLFFSAQPFEITAST
NNEGNLKVRFPLRLTGKIDFLNNYALFLSPSAQQASWQVSARFNQYKYNQ
NFSAGNNENIMEAHVGINGEANLDFLNIPLTIPEMRLPYTIITTPPLKDF
SLWEKTGLKEFLKTTKQSFDLSVKAQYKKNKHRHSITNPLAVLCEFISQS
IKSFDRHFEKNRNNALDFVTKSYNETKIKFDKYKAEKSHDELPRTFQIPG
YTVPVVNVEVSPFTIEMSAFGYVFPKAVSMPSFSILGSDVRVPSYTLILP
SLELPVLHVPRNLKLSLPHFKELCTISHIFIPAMGNITYDFSFKSSVITL
NTNAELFNQSDIVAHLLSSSSSVIDALQYKLEGTTRLTRKRGLKLATALS
LSNKFVEGSHNSTVSLTTKNMEVSVAKTTKAEIPILRMNFKQELNGNTKS
KPTVSSSMEFKYDFNSSMLYSTAKGAVDHKLSLESLTSYFSIESSTKGDV
KGSVLSREYSGTIASEANTYLNSKSTRSSVKLQGTSKIDDIWNLEVKENF
AGEATLQRIYSLWEHSTKNHLQLEGLFFTNGEHTSKATLELSPWQMSALV
QVHASQPSSFHDFPDLGQEVALNANTKNQKIRWKNEVRIHSGSFQSQVEL
SNDQEKAHLDIAGSLEGHLRFLKNIILPVYDKSLWDFLKLDVTTSIGRRQ
HLRVSTAFVYTKNPNGYSFSIPVKVLADKFITPGLKLNDLNSVLVMPTFH
VPFTDLQVPSCKLDFREIQIYKKLRTSSFALNLPTLPEVKFPEVDVLTKY
SQPEDSLIPFFEITVPESQLTVSQFTLPKSVSDGIAALDLNAVANKIADF
ELPTIIVPEQTIEIPSIKFSVPAGIVIPSFQALTARFEVDSPVYNATWSA
SLKNKADYVETVLDSTCSSTVQFLEYELNVLGTHKIEDGTLASKTKGTLA
HRDFSAEYEEDGKFEGLQEWEGKAHLNIKSPAFTDLHLRYQKDKKGISTS
AASPAVGTVGMDMDEDDDFSKWNFYYSPQSSPDKKLTIFKTELRVRESDE
ETQIKVNWEEEAASGLLTSLKDNVPKATGVLYDYVNKYHWEHTGLTLREV
SSKLRRNLQNNAEWVYQGAIRQIDDIDVRFQKAASGTTGTYQEWKDKAQN
LYQELLTQEGQASFQGLKDNVFDGLVRVTQKFHMKVKHLIDSLIDFLNFP
RFQFPGKPGIYTREELCTMFIREVGTVLSQVYSKVHNGSEILFSYFQDLV
ITLPFELRKHKLIDVISMYRELLKDLSKEAQEVFKAIQSLKTTEVLRNLQ
DLLQFIFQLIEDNIKQLKEMKFTYLINYIQDEINTIFNDYIPYVFKLLKE
NLCLNLHKFNEFIQNELQEASQELQQIHQYIMALREEYFDPSIVGWTVKY
YELEEKIVSLIKNLLVALKDFHSEYIVSASNFTSQLSSQVEQFLHRNIQE
YLSILTDPDGKGKEKIAELSATAQEIIKSQAIATKKIISDYHQQFRYKLQ
DFSDQLSDYYEKFIAESKRLIDLSIQNYHTFLIYITELLKKLQSTTVMNP
YMKLAPGELTIIL

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website