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Signal Peptide Database - Viruses
Entry Details
ID
804
Source Database
UniProtKB/Swiss-Prot
UniProtKB/Swiss-Prot Accession Number
Q3I5J5 (Created: 2005-11-22 Updated: 2008-11-25)
UniProtKB/Swiss-Prot Entry Name
SPIKE_BCRP3
Protein Name
Spike glycoprotein
Gene
S
Organism Scientific
Bat coronavirus Rp3/2004
Organism Common
BtCoV/Rp3/2004
Lineage
Viruses
ssRNA positive-strand viruses, no DNA stage
Nidovirales
Coronaviridae
Coronavirus
Coronavirus group 2
Coronavirus group 2b
unclassified Coronavirus group 2b
Protein Length [aa]
1241
Protein Mass [Da]
137560
Features
Type
Description
Status
Start
End
signal peptide
potential
1
15
chain
Spike glycoprotein
16
1241
chain
Spike protein S1
potential
16
653
chain
Spike protein S2
potential
654
1241
transmembrane region
potential
1182
1202
topological domain
Extracellular
potential
16
1181
topological domain
Cytoplasmic
potential
1203
1241
region of interest
Fusion peptide
potential
756
774
region of interest
Heptad repeat 1
888
938
region of interest
Heptad repeat 2
1131
1170
glycosylation site
N-linked (GlcNAc...)
potential
65
65
glycosylation site
N-linked (GlcNAc...)
potential
115
115
glycosylation site
N-linked (GlcNAc...)
potential
124
124
glycosylation site
N-linked (GlcNAc...)
potential
125
125
glycosylation site
N-linked (GlcNAc...)
potential
162
162
glycosylation site
N-linked (GlcNAc...)
potential
231
231
glycosylation site
N-linked (GlcNAc...)
potential
273
273
glycosylation site
N-linked (GlcNAc...)
potential
298
298
glycosylation site
N-linked (GlcNAc...)
potential
322
322
glycosylation site
N-linked (GlcNAc...)
potential
334
334
glycosylation site
N-linked (GlcNAc...)
potential
361
361
glycosylation site
N-linked (GlcNAc...)
potential
575
575
glycosylation site
N-linked (GlcNAc...)
potential
588
588
glycosylation site
N-linked (GlcNAc...)
potential
629
629
glycosylation site
N-linked (GlcNAc...)
potential
677
677
glycosylation site
N-linked (GlcNAc...)
potential
685
685
glycosylation site
N-linked (GlcNAc...)
potential
769
769
glycosylation site
N-linked (GlcNAc...)
potential
1042
1042
glycosylation site
N-linked (GlcNAc...)
potential
1066
1066
glycosylation site
N-linked (GlcNAc...)
potential
1102
1102
glycosylation site
N-linked (GlcNAc...)
potential
1126
1126
glycosylation site
N-linked (GlcNAc...)
potential
1141
1141
glycosylation site
N-linked (GlcNAc...)
potential
1162
1162
helix
913
949
helix
959
976
helix
1134
1137
helix
1141
1171
site
Cleavage
potential
653
654
compositionally biased region
Cys-rich
1203
1222
short sequence motif
KxHxx
by similarity
1237
1241
turn
1172
1176
coiled-coil region
potential
917
961
coiled-coil region
potential
1143
1171
SP Length
15
----+----1----+----2----+----3----+----4----+----5
Signal Peptide
MKILILAFLASLAKA
Sequence
MKILILAFLASLAKA
QEGCGIISRKPQPKMAQVSSSRRGVYYNDDIFRSN
VLHLTQDYFLPFDS
N
LTQYFSLNVDSDRFTYFDNPILDFGDGVYFAATEK
SNVIRGWIFGSTFD
N
TTQSAVIV
N
N
STHIIIRVCNFNLCKEPMYTVSRGA
QQSSWVYQSAF
N
CTYDRVEKSFQLDTAPKTGNFKDLREYVFKNRDGFLSV
YQTYTAVNLPRGLPIGFSVLRPILKLPFGI
N
ITSYRVVMAMFSQTTSNFL
PESAAYYVGNLKYTTFMLSFNE
N
GTITNAIDCAQNPLAELKCTIKNF
N
VS
KGIYQTSNFRVSPTQEVIRFP
N
ITNRCPFDKVF
N
ATRFPNVYAWERTKIS
DCVADYTVLY
N
STSFSTFKCYGVSPSKLIDLCFTSVYADTFLIRSSEVRQ
VAPGETGVIADYNYKLPDDFTGCVIAWNTAKQDQGQYYYRSHRKTKLKPF
ERDLSSDENGVRTLSTYDFYPSVPVAYQATRVVVLSFELLNAPATVCGPK
LSTQLVKNQCVNFNFNGLKGTGVLTESSKRFQSFQQFGRDTSDFTDSVRD
PQTLEILDISPCSFGGVSVITPGT
N
ASSEVAVLYQDV
N
CTDVPAAIHADQ
LTPAWRVYSTGTNVFQTQAGCLIGAEHV
N
ASYECDIPIGAGICASYHTAS
TL
RS
VGQKSIVAYTMSLGAENSIAYA
N
NSIAIPT
N
FSISVTTEVMPVSMA
KTSVDCTMYICGDSLECSNLLLQYGSFCTQLNRALSGIAIEQDKNTQEVF
AQVKQ
MYKTPAIKDFGGF
N
FSQIL
PDPSKPTKRSFIEDLLFNKVTLADAG
FMKQYGECLGDISARDLICAQKFNGLTVLPPLLTDEMIAAYTAALVSGTA
TAGWTFGAGSALQIPFAMQMAYRFNGIGVTQNVLYEN
QKQIANQFNKAIS
QIQESLTTTSTA
LGKL
QDVVNQNAQALNTLVKQLSSNFGAISSVLNDILS
RLDKVEAEVQI
DRLITGRLQSLQTYV
TQQLIRAAEIRASANLAATKMSEC
VLGQSKRVDFCGKGYHLMSFPQAAPHGVVFLHVTYVPSQER
N
FTTAPAIC
HEGKAYFPREGVFVS
N
GTSWFITQRNFYSPQIITTDNTFVAGSCDVVIGI
I
N
NTVYDPLQPELDSFKEELDKYFK
N
HTSP
DVD
LGDI
SGI
NA
SVVNIQKE
IDRLNEVAKNLNESLIDLQEL
GKYEQ
YIKWP
WYVWLGFIAGLIAIVMVTI
LL
CCMTSCCSCLKGACSCGSCC
KFDEDDSEPVLKGV
KLHYT
Original
MKILILAFLASLAKAQEGCGIISRKPQPKMAQVSSSRRGVYYNDDIFRSN
VLHLTQDYFLPFDSNLTQYFSLNVDSDRFTYFDNPILDFGDGVYFAATEK
SNVIRGWIFGSTFDNTTQSAVIVNNSTHIIIRVCNFNLCKEPMYTVSRGA
QQSSWVYQSAFNCTYDRVEKSFQLDTAPKTGNFKDLREYVFKNRDGFLSV
YQTYTAVNLPRGLPIGFSVLRPILKLPFGINITSYRVVMAMFSQTTSNFL
PESAAYYVGNLKYTTFMLSFNENGTITNAIDCAQNPLAELKCTIKNFNVS
KGIYQTSNFRVSPTQEVIRFPNITNRCPFDKVFNATRFPNVYAWERTKIS
DCVADYTVLYNSTSFSTFKCYGVSPSKLIDLCFTSVYADTFLIRSSEVRQ
VAPGETGVIADYNYKLPDDFTGCVIAWNTAKQDQGQYYYRSHRKTKLKPF
ERDLSSDENGVRTLSTYDFYPSVPVAYQATRVVVLSFELLNAPATVCGPK
LSTQLVKNQCVNFNFNGLKGTGVLTESSKRFQSFQQFGRDTSDFTDSVRD
PQTLEILDISPCSFGGVSVITPGTNASSEVAVLYQDVNCTDVPAAIHADQ
LTPAWRVYSTGTNVFQTQAGCLIGAEHVNASYECDIPIGAGICASYHTAS
TLRSVGQKSIVAYTMSLGAENSIAYANNSIAIPTNFSISVTTEVMPVSMA
KTSVDCTMYICGDSLECSNLLLQYGSFCTQLNRALSGIAIEQDKNTQEVF
AQVKQMYKTPAIKDFGGFNFSQILPDPSKPTKRSFIEDLLFNKVTLADAG
FMKQYGECLGDISARDLICAQKFNGLTVLPPLLTDEMIAAYTAALVSGTA
TAGWTFGAGSALQIPFAMQMAYRFNGIGVTQNVLYENQKQIANQFNKAIS
QIQESLTTTSTALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILS
RLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSEC
VLGQSKRVDFCGKGYHLMSFPQAAPHGVVFLHVTYVPSQERNFTTAPAIC
HEGKAYFPREGVFVSNGTSWFITQRNFYSPQIITTDNTFVAGSCDVVIGI
INNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKE
IDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYVWLGFIAGLIAIVMVTI
LLCCMTSCCSCLKGACSCGSCCKFDEDDSEPVLKGVKLHYT
----+----1----+----2----+----3----+----4----+----5
Hydropathies
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Dr. Katja Kapp
, Kassel &
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, Dresden, Germany, last update 2010-06-11