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Signal Peptide Database - Viruses
Entry Details
ID
805
Source Database
UniProtKB/Swiss-Prot
UniProtKB/Swiss-Prot Accession Number
Q8JSP8 (Created: 2007-04-17 Updated: 2008-11-25)
UniProtKB/Swiss-Prot Entry Name
SPIKE_CVPIA
Protein Name
Spike glycoprotein
Gene
S
Organism Scientific
Porcine hemagglutinating encephalomyelitis virus (strain IAF-404)
Organism Common
HEV
Lineage
Viruses
ssRNA positive-strand viruses, no DNA stage
Nidovirales
Coronaviridae
Coronavirus
Coronavirus group 2
Coronavirus group 2a
Protein Length [aa]
1349
Protein Mass [Da]
149649
Features
Type
Description
Status
Start
End
signal peptide
potential
1
17
chain
Spike glycoprotein
by similarity
18
1349
chain
Spike protein S1
by similarity
18
754
chain
Spike protein S2
by similarity
755
1349
transmembrane region
potential
1298
1314
topological domain
Extracellular
potential
18
1297
topological domain
Cytoplasmic
potential
1315
1349
region of interest
Heptad repeat 1
potential
1029
1072
region of interest
Heptad repeat 2
potential
1253
1283
glycosylation site
N-linked (GlcNAc...)
potential
59
59
glycosylation site
N-linked (GlcNAc...)
potential
133
133
glycosylation site
N-linked (GlcNAc...)
potential
198
198
glycosylation site
N-linked (GlcNAc...)
potential
437
437
glycosylation site
N-linked (GlcNAc...)
potential
456
456
glycosylation site
N-linked (GlcNAc...)
potential
635
635
glycosylation site
N-linked (GlcNAc...)
potential
662
662
glycosylation site
N-linked (GlcNAc...)
potential
682
682
glycosylation site
N-linked (GlcNAc...)
potential
700
700
glycosylation site
N-linked (GlcNAc...)
potential
725
725
glycosylation site
N-linked (GlcNAc...)
potential
774
774
glycosylation site
N-linked (GlcNAc...)
potential
923
923
glycosylation site
N-linked (GlcNAc...)
potential
1180
1180
glycosylation site
N-linked (GlcNAc...)
potential
1210
1210
glycosylation site
N-linked (GlcNAc...)
potential
1220
1220
glycosylation site
N-linked (GlcNAc...)
potential
1239
1239
glycosylation site
N-linked (GlcNAc...)
potential
1253
1253
glycosylation site
N-linked (GlcNAc...)
potential
1274
1274
site
Cleavage; by host
by similarity
754
755
compositionally biased region
Cys-rich
1315
1332
coiled-coil region
potential
1029
1073
coiled-coil region
potential
1255
1283
SP Length
17
----+----1----+----2----+----3----+----4----+----5
Signal Peptide
MFFILLITLPSVFAVIG
Sequence
MFFILLITLPSVFAVIG
DLKCNTSSINDVDTGVPSISSEVVDVTNGLGTF
YVLDRVYL
N
TTLLLNGYYPISGATFRNVALKGTRLLSTLWFKPPFLSPFN
DGIFAKVKNSRFSKHGVIYSEFPAITIGSTFV
N
TSYSIVVKPHTSFINGN
LQGFLQISVCQYTMCEYPQTICHPNLGNQRIELWHHDTDVVSCLYRR
N
FT
YDVNADYLYFHFYQEGGTFYAYFTDTGFVTKFLFKLYLGTVLSHYYVMPL
TCDSALSLEYWVTPLTTRQFLLAFDQDGVLYHAVDCASDFMSEIMCKTSS
ITPPTGVYELNGYTVQPVATVYRRIPDLPNCDIEAWLNSKTVSSPLNWER
KIFSNCNFNMGRLMSFIQADSFGCNNIDASRLYGMCFGSITIDKFAIPNS
RKVDLQVGKSGYLQSFNYKIDTAVSSCQLYYSLPAA
N
VSVTHYNPSSWNR
RYGFI
N
QSFGSRGLHDAVYSQQCFNTPNTYCPCRTSQCIGGAGTGTCPVG
TTVRKCFAAVTNATKCTCWCQPDPSTYKGVNAWTCPQSKVSIQPGQHCPG
LGLVEDDCSGNPCTCKPQAFIGWSSETCLQNGRCNIFANFILNDVNSGTT
CSTDLQQGNTNITTDVCVNYDLYGITGQGILIEV
N
ATYYNSWQNLLYDSS
GNLYGFRDYLS
N
RTFLIRSCYSGRVSAVFHA
N
SSEPALMFRNLKCSHVF
N
YTILRQIQLVNYFDSYLGCVVNAY
N
NTASAVSTCDLTVGSGYCVDYVTAL
RSR
RS
FTTGYRFTNFEPFAANLV
N
DSIEPVGGLYEIQIPSEFTIGNLEEF
IQTSSPKVTIDCATFVCGDYAACRQQLAEYGSFCENINAILIEVNELLDT
TQLQVANSLMNGVTLSTKIKDGINFNVDDINFSSVLGCLGSECNRASTRS
AIEDLLFDKVKLSDVGFVQAYN
N
CTGGAEIRDLICVQSYNGIKVLPPLLS
ENQISGYTSAATAASLFPPWTAAAGVPFYLNVQYRINGLGVTMDVLSQNQ
KLIASAFNNALDSIQEGFDATNSALVKI
QAVVNANAEALNNLLQQLSNRF
GAISASLQEILSRLDALEAKAQI
DRLINGRLTALNAYVSQQLSDSTLVKF
SAAQAIEKVNECVKSQSSRINFCGNGNHIISLVQNAPYGLYFIHFSYVPT
KYVTAKVSPGLCIAGDIGISPKSGYFINV
N
NSWMFTGSGYYYPEPITQNN
VVVMSTCAV
N
YTKAPDLML
N
TSTPNLPDFKEELYQWFK
N
QSSLAPDLSFD
YI
N
V
TFLDLQDEMNRLQEAIKVLNHSYINLKDI
GTYEYYVKWPWYVW
LLI
CLAGVVMLVLLFFI
CCCTGCGTSCFKKCGGCF
DDYTGHQEFVIKTSHDD
Original
MFFILLITLPSVFAVIGDLKCNTSSINDVDTGVPSISSEVVDVTNGLGTF
YVLDRVYLNTTLLLNGYYPISGATFRNVALKGTRLLSTLWFKPPFLSPFN
DGIFAKVKNSRFSKHGVIYSEFPAITIGSTFVNTSYSIVVKPHTSFINGN
LQGFLQISVCQYTMCEYPQTICHPNLGNQRIELWHHDTDVVSCLYRRNFT
YDVNADYLYFHFYQEGGTFYAYFTDTGFVTKFLFKLYLGTVLSHYYVMPL
TCDSALSLEYWVTPLTTRQFLLAFDQDGVLYHAVDCASDFMSEIMCKTSS
ITPPTGVYELNGYTVQPVATVYRRIPDLPNCDIEAWLNSKTVSSPLNWER
KIFSNCNFNMGRLMSFIQADSFGCNNIDASRLYGMCFGSITIDKFAIPNS
RKVDLQVGKSGYLQSFNYKIDTAVSSCQLYYSLPAANVSVTHYNPSSWNR
RYGFINQSFGSRGLHDAVYSQQCFNTPNTYCPCRTSQCIGGAGTGTCPVG
TTVRKCFAAVTNATKCTCWCQPDPSTYKGVNAWTCPQSKVSIQPGQHCPG
LGLVEDDCSGNPCTCKPQAFIGWSSETCLQNGRCNIFANFILNDVNSGTT
CSTDLQQGNTNITTDVCVNYDLYGITGQGILIEVNATYYNSWQNLLYDSS
GNLYGFRDYLSNRTFLIRSCYSGRVSAVFHANSSEPALMFRNLKCSHVFN
YTILRQIQLVNYFDSYLGCVVNAYNNTASAVSTCDLTVGSGYCVDYVTAL
RSRRSFTTGYRFTNFEPFAANLVNDSIEPVGGLYEIQIPSEFTIGNLEEF
IQTSSPKVTIDCATFVCGDYAACRQQLAEYGSFCENINAILIEVNELLDT
TQLQVANSLMNGVTLSTKIKDGINFNVDDINFSSVLGCLGSECNRASTRS
AIEDLLFDKVKLSDVGFVQAYNNCTGGAEIRDLICVQSYNGIKVLPPLLS
ENQISGYTSAATAASLFPPWTAAAGVPFYLNVQYRINGLGVTMDVLSQNQ
KLIASAFNNALDSIQEGFDATNSALVKIQAVVNANAEALNNLLQQLSNRF
GAISASLQEILSRLDALEAKAQIDRLINGRLTALNAYVSQQLSDSTLVKF
SAAQAIEKVNECVKSQSSRINFCGNGNHIISLVQNAPYGLYFIHFSYVPT
KYVTAKVSPGLCIAGDIGISPKSGYFINVNNSWMFTGSGYYYPEPITQNN
VVVMSTCAVNYTKAPDLMLNTSTPNLPDFKEELYQWFKNQSSLAPDLSFD
YINVTFLDLQDEMNRLQEAIKVLNHSYINLKDIGTYEYYVKWPWYVWLLI
CLAGVVMLVLLFFICCCTGCGTSCFKKCGGCFDDYTGHQEFVIKTSHDD
----+----1----+----2----+----3----+----4----+----5
Hydropathies
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Dr. Katja Kapp
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, Dresden, Germany, last update 2010-06-11