Signal Peptide Database

Signal Peptide Database - Drosophila melanogaster

Entry Details

29266

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

Q9VAC5 (Created: 2001-06-20 Updated: 2008-11-25)

UniProtKB/Swiss-Prot Entry Name

ADA17_DROME

Protein Name

ADAM 17-like protease

Gene

Tace

Organism Scientific

Drosophila melanogaster

Organism Common

Fruit fly

Lineage

Eukaryota
  Metazoa
    Arthropoda
      Hexapoda
        Insecta
          Pterygota
            Neoptera
              Endopterygota
                Diptera
                  Brachycera
                    Muscomorpha
                      Ephydroidea
                        Drosophilidae
                          Drosophila
                            Sophophora

Protein Length [aa]

732

Protein Mass [Da]

83081

Features

TypeDescriptionStatusStartEnd
signal peptide      potential   1   28
chain   ADAM 17-like protease      212   732
disulfide bond      by similarity   225   328
disulfide bond      by similarity   360   462
disulfide bond      by similarity   416   446
disulfide bond      by similarity   530   551
disulfide bond      by similarity   569   578
disulfide bond      by similarity   574   586
disulfide bond      by similarity   588   595
transmembrane region      potential   663   683
topological domain   Extracellular   potential   212   662
topological domain   Cytoplasmic   potential   684   732
domain   Peptidase M12B      223   467
domain   Disintegrin      468   559
region of interest   Crambin-like      598   662
glycosylation site   N-linked (GlcNAc...)   potential   100   100
glycosylation site   N-linked (GlcNAc...)   potential   263   263
glycosylation site   N-linked (GlcNAc...)   potential   492   492
glycosylation site   N-linked (GlcNAc...)   potential   604   604
active site      by similarity   400   400
splice variant   (in isoform B)      1   427
propeptide      by similarity   29   211
metal ion-binding site   Zinc; in inhibited form   by similarity   183   183
metal ion-binding site   Zinc; catalytic   by similarity   399   399
metal ion-binding site   Zinc; catalytic   by similarity   403   403
metal ion-binding site   Zinc; catalytic   by similarity   409   409
compositionally biased region   Cys-rich      560   599
short sequence motif   Cysteine switch   by similarity   181   188

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MFTKCISCCGLAIISVFFACLFVENCAA

Sequence

MFTKCISCCGLAIISVFFACLFVENCAALQKTLRHYEIFHKDDVVHRVVK
RGAKHSTNPFNTIKEVEFTTLGKNFRLILHPHRDVLHSKFRAYAVDADGN
ETVVHMDHDSFYSGRVFGELESSVRAHIEDGTMTMSIHLPEETYHIEPSW
RHLPEAKKDTMVAYKASDVKVHKNEAGATPKTCGYIKEGLELEDKEHGDT
LDNELHTREKRQSDQYEYTPTKTRCPLLLVADYRFFQEMGGGNTKTTINY
LISLIDRVHKIYNDTVWQDRSDQEGFKGMGFVIKKIVVHSEPTRLRGGEA
HYNMIREKWDVRNLLEVFSREYSHKDFCLAHLFTDLKFEGGILGLAYVGS
PRRNSVGGICTPEYFKNGYTLYLNSGLSSSRNHYGQRVITREADLVTAHE
FGHNWGSEHDPDIPECSPSASQGGSFLMYTYSVSGYDVNNKKFSPCSLRS
IRKVLQAKSGRCFSEPEESFCGNLRVEGDEQCDAGLLGTEDNDSCCDKNC
KLRRNQGAMCSDKNSPCCQNCQFMASGMKCREAQYATCEQEARCTGAHAE
CPKSPAMADGTTCQERGQCRNGKCVPYCETQGLQSCMCDIIADACKRCCR
MSINETCFPVEPPDVLPDGTPCITGFCNKGVCEKTIQDVVERFWDIIEEI
NVAKTLRFLKDNIVMAVVLVTAVFWIPISCVISYFDRKKLRHEMKLIEWS
QKLDLIHPSDERRRVIHIRVPRQKISVARACN

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website