Signal Peptide Database

Signal Peptide Database - Drosophila melanogaster

Entry Details

6738

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

Q9VYX7 (Created: 2005-05-10 Updated: 2009-01-20)

UniProtKB/Swiss-Prot Entry Name

PGPSA_DROME

Protein Name

Peptidoglycan-recognition protein-SA

Gene

PGRP-SA

Organism Scientific

Drosophila melanogaster

Organism Common

Fruit fly

Lineage

Eukaryota
  Metazoa
    Arthropoda
      Hexapoda
        Insecta
          Pterygota
            Neoptera
              Endopterygota
                Diptera
                  Brachycera
                    Muscomorpha
                      Ephydroidea
                        Drosophilidae
                          Drosophila
                            Sophophora

Protein Length [aa]

203

Protein Mass [Da]

22260

Features

TypeDescriptionStatusStartEnd
signal peptide         1   26
chain   Peptidoglycan-recognition protein-SA      27   203
disulfide bond         37   160
disulfide bond         74   80
strand         59   68
strand         101   106
strand         112   116
strand         123   125
strand         129   139
strand         142   144
strand         166   175
strand         180   182
helix         44   46
helix         76   93
helix         148   163
helix         176   178
helix         187   193
binding site   Substrate   probable   87   87
binding site   Substrate   probable   90   90
binding site   Substrate   probable   97   97
binding site   Substrate   probable   102   102
binding site   Substrate   probable   182   182
mutagenesis site   Increases PGN-binding and activation of Toll pathway      0   0
mutagenesis site   Does not affect activation of Toll pathway      0   0
mutagenesis site   Abolishes L,D-carboxypeptidase activity on DAP-type PGN      0   0
mutagenesis site   Strongly reduces PGN-binding and activation of Toll pathway      0   0
mutagenesis site   Abolishes activation of Toll pathway      0   0
mutagenesis site   In seml; induces susceptibility to Gram-positive bacterial infection      0   0
mutagenesis site   Strongly reduces PGN-binding and activation of Toll pathway      0   0
mutagenesis site   Strongly reduces PGN-binding and activation of Toll pathway      0   0
mutagenesis site   Abolishes PGN-binding and activation of Toll pathway. Abolishes L,D-carboxypeptidase activity on DAP-type PGN      0   0
mutagenesis site   Abolishes PGN-binding and activation of Toll pathway      0   0
mutagenesis site   Strongly reduces PGN-binding      0   0
mutagenesis site   Strongly reduces PGN-binding and activation of Toll pathway      0   0

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MQPVRFGSPWIMAIGLVLLLLAFVSA

Sequence

MQPVRFGSPWIMAIGLVLLLLAFVSAGKSRQRSPANCPTIKLKRQWGGKP
SLGLHYQVRPIRYVVIHHTVTGECSGLLKCAEILQNMQAYHQNELDFNDI
SYNFLIGNDGIVYEGTGWGLRGAHTYGYNAIGTGIAFIGNFVDKLPSDAA
LQAAKDLLACGVQQGELSEDYALIAGSQVISTQSPGLTLYNEIQEWPHWL
SNP

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website