Signal Peptide Database

Signal Peptide Database - Mammalia

Entry Details

129

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

P20138 (Created: 1991-02-01 Updated: 2008-12-16)

UniProtKB/Swiss-Prot Entry Name

CD33_HUMAN

Protein Name

Myeloid cell surface antigen CD33

Gene

CD33

Organism Scientific

Homo sapiens

Organism Common

Human

Lineage

Eukaryota
  Metazoa
    Chordata
      Craniata
        Vertebrata
          Euteleostomi
            Mammalia
              Eutheria
                Euarchontoglires
                  Primates
                    Haplorrhini
                      Catarrhini
                        Hominidae
                          Homo

Protein Length [aa]

364

Protein Mass [Da]

39825

Features

TypeDescriptionStatusStartEnd
signal peptide      potential   1   17
chain   Myeloid cell surface antigen CD33      18   364
disulfide bond      by similarity   36   169
disulfide bond      by similarity   41   101
disulfide bond      potential   163   212
transmembrane region      potential   260   282
topological domain   Extracellular   potential   18   259
topological domain   Cytoplasmic   potential   283   364
domain   Ig-like V-type      19   135
domain   Ig-like C2-type      145   228
modified residue   Phosphotyrosine      340   340
modified residue   Phosphotyrosine      358   358
glycosylation site   N-linked (GlcNAc...)   potential   100   100
glycosylation site   N-linked (GlcNAc...)   potential   113   113
glycosylation site   N-linked (GlcNAc...)   potential   160   160
glycosylation site   N-linked (GlcNAc...)   potential   209   209
glycosylation site   N-linked (GlcNAc...)   potential   230   230
sequence variant   (in dbSNP:rs4082929)      0   0
sequence variant   (in dbSNP:rs988337)      0   0
sequence variant   (in dbSNP:rs2271652)      0   0
sequence variant   (in dbSNP:rs34919259)      0   0
sequence variant   (in dbSNP:rs2455069)      0   0
sequence variant   (in dbSNP:rs35814802)      0   0
sequence variant   (in dbSNP:rs12459419)      0   0
sequence variant   (in dbSNP:rs35112940)      0   0
sequence variant   (in dbSNP:rs35632246)      0   0
sequence variant   (in dbSNP:rs11882250)      0   0
binding site   Sialic acid   by similarity   119   119
short sequence motif   ITIM motif 1      338   343
short sequence motif   ITIM motif 2      356   361
mutagenesis site   Abolishes binding to PTPN6 and PTPN11. Increases binding of red blood cells      0   0
mutagenesis site   Reduces binding to PTPN6      0   0

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MPLLLLLPLLWAGALAM

Sequence

MPLLLLLPLLWAGALAMDPNFWLQVQESVTVQEGLCVLVPCTFFHPIPYY
DKNSPVHGYWFREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNN
CSLSIVDARRRDNGSYFFRMERGSTKYSYKSPQLSVHVTDLTHRPKILIP
GTLEPGHSKNLTCSVSWACEQGTPPIFSWLSAAPTSLGPRTTHSSVLIIT
PRPQDHGTNLTCQVKFAGAGVTTERTIQLNVTYVPQNPTTGIFPGDGSGK
QETRAGVVHGAIGGAGVTALLALCLCLIFFIVKTHRRKAARTAVGRNDTH
PTTGSASPKHQKKSKLHGPTETSSCSGAAPTVEMDEELHYASLNFHGMNP
SKDTSTEYSEVRTQ

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website