Signal Peptide Database

Signal Peptide Database - Mammalia

Entry Details

138

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

P11597 (Created: 1989-10-01 Updated: 2009-01-20)

UniProtKB/Swiss-Prot Entry Name

CETP_HUMAN

Protein Name

Cholesteryl ester transfer protein

Gene

CETP

Organism Scientific

Homo sapiens

Organism Common

Human

Lineage

Eukaryota
  Metazoa
    Chordata
      Craniata
        Vertebrata
          Euteleostomi
            Mammalia
              Eutheria
                Euarchontoglires
                  Primates
                    Haplorrhini
                      Catarrhini
                        Hominidae
                          Homo

Protein Length [aa]

493

Protein Mass [Da]

54756

Features

TypeDescriptionStatusStartEnd
signal peptide         1   17
chain   Cholesteryl ester transfer protein      18   493
glycosylation site   N-linked (GlcNAc...)   potential   105   105
glycosylation site   N-linked (GlcNAc...)      257   257
glycosylation site   N-linked (GlcNAc...)      358   358
glycosylation site   N-linked (GlcNAc...)   potential   413   413
sequence variant   (in dbSNP:rs5882)      0   0
sequence variant   (in dbSNP:rs2228667)      0   0
sequence variant   (in CETP deficiency; dbSNP:rs2303790)      0   0
sequence variant   (in dbSNP:rs1800777)      0   0
sequence variant   (in dbSNP:rs5887)      0   0
sequence variant   (in dbSNP:rs5880)      0   0
sequence variant   (in dbSNP:rs34855278)      0   0
sequence variant   (in dbSNP:rs5881)      0   0
sequence variant   (in hyperalphalipoproteinemia; reduced secretion into plasma)      0   0
sequence variant   (in hyperalphalipoproteinemia; reduced secretion into plasma)      0   0
sequence variant   (in dbSNP:rs34716057)      0   0
sequence variant   (in dbSNP:rs34065661)      0   0
splice variant   (in isoform 2)      251   310
mutagenesis site   Not secreted      0   0
mutagenesis site   Not secreted      0   0
mutagenesis site   Reduces cholesteryl ester transfer by 60%      0   0
mutagenesis site   Not secreted      0   0
mutagenesis site   Not secreted      0   0
mutagenesis site   Not secreted      0   0
mutagenesis site   Reduces triglyceride transfer 5- fold. Slight reduction of cholesteryl ester transfer      0   0
mutagenesis site   Reduces triglyceride transfer 10- fold. Slight reduction of cholesteryl ester transfer      0   0
mutagenesis site   Reduces triglyceride transfer 10- fold. No effect on cholesteryl ester transfer      0   0
mutagenesis site   Reduces triglyceride transfer and cholesteryl ester transfer 5-fold      0   0
mutagenesis site   Reduces activity by 60%      0   0

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MLAATVLTLALLGNAHA

Sequence

MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQT
AFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSID
VSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDS
GRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQI
CKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHK
GHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISC
QNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLS
LLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALM
NSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website