Signal Peptide Database - Mammalia

 Entry Details
ID   141
Source Database   UniProtKB/Swiss-Prot
UniProtKB/Swiss-Prot Accession Number   P05156    (Created: 1987-08-13 Updated: 2009-01-20)
UniProtKB/Swiss-Prot Entry Name   CFAI_HUMAN
Protein Name   Complement factor I
Gene   CFI
Organism Scientific   Homo sapiens
Organism Common   Human
Lineage   Eukaryota
  Metazoa
    Chordata
      Craniata
        Vertebrata
          Euteleostomi
            Mammalia
              Eutheria
                Euarchontoglires
                  Primates
                    Haplorrhini
                      Catarrhini
                        Hominidae
                          Homo
Protein Length [aa]   583
Protein Mass [Da]   65720
Features  
TypeDescriptionStatusStartEnd
signal peptide         1   18
chain   Complement factor I      19   583
chain   Complement factor I heavy chain      19   335
chain   Complement factor I light chain      340   583
disulfide bond      by similarity   154   214
disulfide bond      by similarity   186   196
disulfide bond      by similarity   229   247
disulfide bond      by similarity   241   256
disulfide bond      by similarity   259   271
disulfide bond      by similarity   266   284
disulfide bond      by similarity   278   293
disulfide bond      by similarity   365   381
disulfide bond      by similarity   467   531
disulfide bond      by similarity   495   510
disulfide bond      by similarity   521   550
domain   SRCR      114   212
domain   LDL-receptor class A 1      213   257
domain   LDL-receptor class A 2      258   294
domain   Peptidase S1      340   574
glycosylation site   N-linked (GlcNAc...)      70   70
glycosylation site   N-linked (GlcNAc...)      103   103
glycosylation site   N-linked (GlcNAc...)      177   177
glycosylation site   N-linked (GlcNAc...)      464   464
glycosylation site   N-linked (GlcNAc...)   potential   494   494
glycosylation site   N-linked (GlcNAc...)      536   536
sequence variant   (in CFI deficiency)      0   0
sequence variant   (in dbSNP:rs11098044)      0   0
sequence variant   (in predisposes to atypical HUS)      0   0
sequence variant   (in CFI deficiency)      0   0
sequence variant   (in associated with atypical HUS)      0   0
active site   Charge relay system   by similarity   380   380
active site   Charge relay system   by similarity   429   429
active site   Charge relay system   by similarity   525   525
SP Length   18
 ----+----1----+----2----+----3----+----4----+----5
Signal Peptide MKLLHVFLLFLCFHLRFC
Sequence MKLLHVFLLFLCFHLRFCKVTYTSQEDLVEKKCLAKKYTHLSCDKVFCQP
WQRCIEGTCVCKLPYQCPK
NGTAVCATNRRSFPTYCQQKSLECLHPGTKF
LN
NGTCTAEGKFSVSLKHGNTDSEGIVEVKLVDQDKTMFICKSSWSMREA
NVACLDLGFQQGADTQRRFKLSDLSI
NSTECLHVHCRGLETSLAECTFTK
RRTMGYQDFADV
VCYTQKADSPMDDFFQCVNGKYISQMKACDGINDCGDQ
SDELCCK
ACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCAGFASVA
QEETEILTADMDAERRRIKSLLPKLSCGVKNRMHI
RRKRIVGGKRAQLGD
LPWQVAIKDASGITCGGIYIGGCWILTAA
HCLRASKTHRYQIWTTVVDWI
HPDLKRIVIEYVDRIIFHENYNAGTYQN
DIALIEMKKDGNKKDCELPRSI
PACVPWSPYLFQP
NDTCIVSGWGREKDNERVFSLQWGEVKLISNCSKFYG
NRFYEKEMECAGTYDGSIDACKGD
SGGPLVCMDANNVTYVWGVVSWGENC
GKPEFPGVYTKVANYFDWISYHVG
RPFISQYNV
Original MKLLHVFLLFLCFHLRFCKVTYTSQEDLVEKKCLAKKYTHLSCDKVFCQP
WQRCIEGTCVCKLPYQCPKNGTAVCATNRRSFPTYCQQKSLECLHPGTKF
LNNGTCTAEGKFSVSLKHGNTDSEGIVEVKLVDQDKTMFICKSSWSMREA
NVACLDLGFQQGADTQRRFKLSDLSINSTECLHVHCRGLETSLAECTFTK
RRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKYISQMKACDGINDCGDQ
SDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCAGFASVA
QEETEILTADMDAERRRIKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGD
LPWQVAIKDASGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWI
HPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDGNKKDCELPRSI
PACVPWSPYLFQPNDTCIVSGWGREKDNERVFSLQWGEVKLISNCSKFYG
NRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENC
GKPEFPGVYTKVANYFDWISYHVGRPFISQYNV
 ----+----1----+----2----+----3----+----4----+----5
Hydropathies  
 

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