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Signal Peptide Database - Mammalia
Entry Details
ID
141
Source Database
UniProtKB/Swiss-Prot
UniProtKB/Swiss-Prot Accession Number
P05156 (Created: 1987-08-13 Updated: 2009-01-20)
UniProtKB/Swiss-Prot Entry Name
CFAI_HUMAN
Protein Name
Complement factor I
Gene
CFI
Organism Scientific
Homo sapiens
Organism Common
Human
Lineage
Eukaryota
Metazoa
Chordata
Craniata
Vertebrata
Euteleostomi
Mammalia
Eutheria
Euarchontoglires
Primates
Haplorrhini
Catarrhini
Hominidae
Homo
Protein Length [aa]
583
Protein Mass [Da]
65720
Features
Type
Description
Status
Start
End
signal peptide
1
18
chain
Complement factor I
19
583
chain
Complement factor I heavy chain
19
335
chain
Complement factor I light chain
340
583
disulfide bond
by similarity
154
214
disulfide bond
by similarity
186
196
disulfide bond
by similarity
229
247
disulfide bond
by similarity
241
256
disulfide bond
by similarity
259
271
disulfide bond
by similarity
266
284
disulfide bond
by similarity
278
293
disulfide bond
by similarity
365
381
disulfide bond
by similarity
467
531
disulfide bond
by similarity
495
510
disulfide bond
by similarity
521
550
domain
SRCR
114
212
domain
LDL-receptor class A 1
213
257
domain
LDL-receptor class A 2
258
294
domain
Peptidase S1
340
574
glycosylation site
N-linked (GlcNAc...)
70
70
glycosylation site
N-linked (GlcNAc...)
103
103
glycosylation site
N-linked (GlcNAc...)
177
177
glycosylation site
N-linked (GlcNAc...)
464
464
glycosylation site
N-linked (GlcNAc...)
potential
494
494
glycosylation site
N-linked (GlcNAc...)
536
536
sequence variant
(in CFI deficiency)
0
0
sequence variant
(in dbSNP:rs11098044)
0
0
sequence variant
(in predisposes to atypical HUS)
0
0
sequence variant
(in CFI deficiency)
0
0
sequence variant
(in associated with atypical HUS)
0
0
active site
Charge relay system
by similarity
380
380
active site
Charge relay system
by similarity
429
429
active site
Charge relay system
by similarity
525
525
SP Length
18
----+----1----+----2----+----3----+----4----+----5
Signal Peptide
MKLLHVFLLFLCFHLRFC
Sequence
MKLLHVFLLFLCFHLRFC
KVTYTSQEDLVEKKCLAKKYTHLSCDKVFCQP
WQRCIEGTCVCKLPYQCPK
N
GTAVCATNRRSFPTYCQQKSLECLHPGTKF
LN
N
GTCTAEGKFS
VSLKHGNTDSEGIVEVKLVDQDKTMFICKSSWSMREA
NVACLDLGFQQGADTQRRFKLSDLSI
N
STECLHVHCRGLETSLAECTFTK
RRTMGYQDFADV
VCYTQKADSPMDDFFQCVNGKYISQMKACDGINDCGDQ
SDELCCK
ACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCA
GFASVA
QEETEILTADMDAERRRIKSLLPKLSCGVKNRMHI
RRKR
IVGGKRAQLGD
LPWQVAIKDASGITCGGIYIGGCWILTAA
H
CLRASKTHRYQIWTTVVDWI
HPDLKRIVIEYVDRIIFHENYNAGTYQN
D
IALIEMKKDGNKKDCELPRSI
PACVPWSPYLFQP
N
DTCIVSGWGREKDNERVFSLQWGEVKLIS
N
CSKFYG
NRFYEKEMECAGTYDGSIDACKGD
S
GGPLVCMDAN
N
VTYVWGVVSWGENC
GKPEFPGVYTKVANYFDWISYHVG
RPFISQYNV
Original
MKLLHVFLLFLCFHLRFCKVTYTSQEDLVEKKCLAKKYTHLSCDKVFCQP
WQRCIEGTCVCKLPYQCPKNGTAVCATNRRSFPTYCQQKSLECLHPGTKF
LNNGTCTAEGKFSVSLKHGNTDSEGIVEVKLVDQDKTMFICKSSWSMREA
NVACLDLGFQQGADTQRRFKLSDLSINSTECLHVHCRGLETSLAECTFTK
RRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKYISQMKACDGINDCGDQ
SDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCAGFASVA
QEETEILTADMDAERRRIKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGD
LPWQVAIKDASGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWI
HPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDGNKKDCELPRSI
PACVPWSPYLFQPNDTCIVSGWGREKDNERVFSLQWGEVKLISNCSKFYG
NRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENC
GKPEFPGVYTKVANYFDWISYHVGRPFISQYNV
----+----1----+----2----+----3----+----4----+----5
Hydropathies
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Dr. Katja Kapp
, Kassel &
thpr.net e. K.
, Dresden, Germany, last update 2010-06-11