Signal Peptide Database

Signal Peptide Database - Mammalia

Entry Details

141

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

P05156 (Created: 1987-08-13 Updated: 2009-01-20)

UniProtKB/Swiss-Prot Entry Name

CFAI_HUMAN

Protein Name

Complement factor I

Gene

CFI

Organism Scientific

Homo sapiens

Organism Common

Human

Lineage

Eukaryota
  Metazoa
    Chordata
      Craniata
        Vertebrata
          Euteleostomi
            Mammalia
              Eutheria
                Euarchontoglires
                  Primates
                    Haplorrhini
                      Catarrhini
                        Hominidae
                          Homo

Protein Length [aa]

583

Protein Mass [Da]

65720

Features

TypeDescriptionStatusStartEnd
signal peptide         1   18
chain   Complement factor I      19   583
chain   Complement factor I heavy chain      19   335
chain   Complement factor I light chain      340   583
disulfide bond      by similarity   154   214
disulfide bond      by similarity   186   196
disulfide bond      by similarity   229   247
disulfide bond      by similarity   241   256
disulfide bond      by similarity   259   271
disulfide bond      by similarity   266   284
disulfide bond      by similarity   278   293
disulfide bond      by similarity   365   381
disulfide bond      by similarity   467   531
disulfide bond      by similarity   495   510
disulfide bond      by similarity   521   550
domain   SRCR      114   212
domain   LDL-receptor class A 1      213   257
domain   LDL-receptor class A 2      258   294
domain   Peptidase S1      340   574
glycosylation site   N-linked (GlcNAc...)      70   70
glycosylation site   N-linked (GlcNAc...)      103   103
glycosylation site   N-linked (GlcNAc...)      177   177
glycosylation site   N-linked (GlcNAc...)      464   464
glycosylation site   N-linked (GlcNAc...)   potential   494   494
glycosylation site   N-linked (GlcNAc...)      536   536
sequence variant   (in CFI deficiency)      0   0
sequence variant   (in dbSNP:rs11098044)      0   0
sequence variant   (in predisposes to atypical HUS)      0   0
sequence variant   (in CFI deficiency)      0   0
sequence variant   (in associated with atypical HUS)      0   0
active site   Charge relay system   by similarity   380   380
active site   Charge relay system   by similarity   429   429
active site   Charge relay system   by similarity   525   525

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MKLLHVFLLFLCFHLRFC

Sequence

MKLLHVFLLFLCFHLRFCKVTYTSQEDLVEKKCLAKKYTHLSCDKVFCQP
WQRCIEGTCVCKLPYQCPKNGTAVCATNRRSFPTYCQQKSLECLHPGTKF
LNNGTCTAEGKFSVSLKHGNTDSEGIVEVKLVDQDKTMFICKSSWSMREA
NVACLDLGFQQGADTQRRFKLSDLSINSTECLHVHCRGLETSLAECTFTK
RRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKYISQMKACDGINDCGDQ
SDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCAGFASVA
QEETEILTADMDAERRRIKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGD
LPWQVAIKDASGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWI
HPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDGNKKDCELPRSI
PACVPWSPYLFQPNDTCIVSGWGREKDNERVFSLQWGEVKLISNCSKFYG
NRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENC
GKPEFPGVYTKVANYFDWISYHVGRPFISQYNV

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website