Signal Peptide Database

Signal Peptide Database - Mammalia

Entry Details

236

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

Q8NFT8 (Created: 2006-10-17 Updated: 2008-12-16)

UniProtKB/Swiss-Prot Entry Name

DNER_HUMAN

Protein Name

Delta and Notch-like epidermal growth factor-related receptor

Gene

DNER

Organism Scientific

Homo sapiens

Organism Common

Human

Lineage

Eukaryota
  Metazoa
    Chordata
      Craniata
        Vertebrata
          Euteleostomi
            Mammalia
              Eutheria
                Euarchontoglires
                  Primates
                    Haplorrhini
                      Catarrhini
                        Hominidae
                          Homo

Protein Length [aa]

737

Protein Mass [Da]

78475

Features

TypeDescriptionStatusStartEnd
signal peptide      potential   1   34
chain   Delta and Notch-like epidermal growth factor-related receptor      35   737
disulfide bond      by similarity   48   59
disulfide bond      by similarity   53   80
disulfide bond      by similarity   82   91
disulfide bond      by similarity   98   108
disulfide bond      by similarity   103   121
disulfide bond      by similarity   123   132
disulfide bond      by similarity   319   336
disulfide bond      by similarity   338   347
disulfide bond      by similarity   353   364
disulfide bond      by similarity   358   378
disulfide bond      by similarity   380   389
disulfide bond      by similarity   396   407
disulfide bond      by similarity   401   416
disulfide bond      by similarity   418   427
disulfide bond      by similarity   434   445
disulfide bond      by similarity   439   454
disulfide bond      by similarity   456   465
disulfide bond      by similarity   472   482
disulfide bond      by similarity   477   491
disulfide bond      by similarity   493   502
disulfide bond      by similarity   509   520
disulfide bond      by similarity   514   529
disulfide bond      by similarity   531   540
disulfide bond      by similarity   547   558
disulfide bond      by similarity   552   567
disulfide bond      by similarity   569   578
disulfide bond      by similarity   585   596
disulfide bond      by similarity   590   605
disulfide bond      by similarity   607   616
transmembrane region      potential   641   661
topological domain   Extracellular   potential   35   640
topological domain   Cytoplasmic   potential   662   737
domain   EGF-like 1      44   92
domain   EGF-like 2      94   133
domain   EGF-like 3      309   348
domain   EGF-like 4      349   390
domain   EGF-like 5      392   428
domain   EGF-like 6      430   466
domain   EGF-like 7      468   503
domain   EGF-like 8; calcium-binding   potential   505   541
domain   EGF-like 9      543   579
domain   Follistatin-like      546   568
domain   EGF-like 10; calcium-binding   potential   581   617
region of interest   Interaction with NOTCH1   by similarity   44   133
region of interest   Interaction with AP1G1 and somatodendritic targeting   by similarity   677   680
modified residue   Phosphotyrosine   by similarity   711   711
modified residue   Phosphotyrosine   by similarity   718   718
modified residue   Phosphotyrosine   by similarity   721   721
glycosylation site   N-linked (GlcNAc...)      223   223
glycosylation site   N-linked (GlcNAc...)   potential   564   564
sequence variant   (in dbSNP:rs17853365)      0   0

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MQPRRAQAPGAQLLPALALLLLLLGAGPRGSSLA

Sequence

MQPRRAQAPGAQLLPALALLLLLLGAGPRGSSLANPVPAAPLSAPGPCAA
QPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCAS
NPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAP
RQLQPVPATQEPDKILPRSQATVTLPTWQPKTGQKVVEMKWDQVEVIPDI
ACGNASSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTATGFQQC
SLIDGRSVTPLQASGGLVLLEEMLALGNNHFIGFVNDSVTKSIVALRLTL
VVKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEY
DACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDP
CRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGV
HFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYHGL
YCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANV
SCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQP
NGYNCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVAF
ILMLIILIVGICRISRIEYQGSSRPAYEEFYNCRSIDSEFSNAIASIRHA
RFGKKSRPAMYDVSPIAYEDYSPDDKPLVTLIKTKDL

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website