Signal Peptide Database

Signal Peptide Database - Mammalia

Entry Details

264

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

Q6UWV6 (Created: 2005-03-15 Updated: 2009-01-20)

UniProtKB/Swiss-Prot Entry Name

ENPP7_HUMAN

Protein Name

Ectonucleotide pyrophosphatase/phosphodiesterase family member 7

Gene

ENPP7

Organism Scientific

Homo sapiens

Organism Common

Human

Lineage

Eukaryota
  Metazoa
    Chordata
      Craniata
        Vertebrata
          Euteleostomi
            Mammalia
              Eutheria
                Euarchontoglires
                  Primates
                    Haplorrhini
                      Catarrhini
                        Hominidae
                          Homo

Protein Length [aa]

458

Protein Mass [Da]

51494

Features

TypeDescriptionStatusStartEnd
signal peptide         1   21
chain   Ectonucleotide pyrophosphatase/phosphodiesterase family member 7      22   458
transmembrane region      potential   434   454
region of interest   Required for enzyme activity      72   78
glycosylation site   N-linked (GlcNAc...)      100   100
glycosylation site   N-linked (GlcNAc...)      121   121
glycosylation site   N-linked (GlcNAc...)      146   146
glycosylation site   N-linked (GlcNAc...)      168   168
glycosylation site   N-linked (GlcNAc...)      267   267
sequence variant   (in dbSNP:rs8074547)      0   0
active site      by similarity   75   75
mutagenesis site   Strongly reduces N-glycosylation and enzyme activity; when associated with Q-100; Q-121; Q-146 and Q-168      0   0
mutagenesis site   Strongly reduces N-glycosylation and enzyme activity; when associated with Q-100; Q-121; Q-168 and Q-267      0   0
mutagenesis site   Strongly reduces N-glycosylation and enzyme activity; when associated with Q-100; Q-146; Q-168 and Q-267      0   0
mutagenesis site   Strongly reduces N-glycosylation and enzyme activity; when associated with Q-100; Q-146; Q-168 and Q-267      0   0
mutagenesis site   Strongly reduces N-glycosylation and enzyme activity; when associated with Q-121; Q-146; Q-168 and Q-267      0   0
mutagenesis site   Strongly reduces activity      0   0
mutagenesis site   Loss of activity      0   0
mutagenesis site   Loss of activity      0   0

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MRGLAVLLTVALATLLAPGAG

Sequence

MRGLAVLLTVALATLLAPGAGAPVQSQGSQNKLLLVSFDGFRWNYDQDVD
TPNLDAMARDGVKARYMTPAFVTMTSPCHFTLVTGKYIENHGVVHNMYYN
TTSKVKLPYHATLGIQRWWDNGSVPIWITAQRQGLRAGSFFYPGGNVTYQ
GVAVTRSRKEGIAHNYKNETEWRANIDTVMAWFTEEDLDLVTLYFGEPDS
TGHRYGPESPERREMVRQVDRTVGYLRESIARNHLTDRLNLIITSDHGMT
TVDKRAGDLVEFHKFPNFTFRDIEFELLDYGPNGMLLPKEGRLEKVYDAL
KDAHPKLHVYKKEAFPEAFHYANNPRVTPLLMYSDLGYVIHGRINVQFNN
GEHGFDNKDMDMKTIFRAVGPSFRAGLEVEPFESVHVYELMCRLLGIVPE
ANDGHLATLLPMLHTESALPPDGRPTLLPKGRSALPPSSRPLLVMGLLGT
VILLSEVA

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website