Signal Peptide Database

Signal Peptide Database - Mammalia

Entry Details

275

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

O75460 (Created: 2004-08-16 Updated: 2009-01-20)

UniProtKB/Swiss-Prot Entry Name

ERN1_HUMAN

Protein Name

Serine/threonine-protein kinase/endoribonuclease IRE1

Gene

ERN1

Organism Scientific

Homo sapiens

Organism Common

Human

Lineage

Eukaryota
  Metazoa
    Chordata
      Craniata
        Vertebrata
          Euteleostomi
            Mammalia
              Eutheria
                Euarchontoglires
                  Primates
                    Haplorrhini
                      Catarrhini
                        Hominidae
                          Homo

Protein Length [aa]

977

Protein Mass [Da]

109735

Features

TypeDescriptionStatusStartEnd
signal peptide      potential   1   18
chain   Serine/threonine-protein kinase/endoribonuclease IRE1      19   977
transmembrane region      potential   444   464
topological domain   Lumenal   potential   19   443
topological domain   Cytoplasmic   potential   465   977
domain   Protein kinase      571   832
domain   KEN      835   963
glycosylation site   N-linked (GlcNAc...)   potential   176   176
sequence variant   (in a lung adenocarcinoma sample; somatic mutation)      0   0
sequence variant   (in dbSNP:rs55869215)      0   0
sequence variant   (in a renal clear cell carcinoma sample; somatic mutation)      0   0
sequence variant         0   0
sequence variant   (in a glioblastoma multiforme sample; somatic mutation)      0   0
sequence variant   (in an ovarian serous carcinoma sample; somatic mutation)      0   0
sequence variant   (in a gastric adenocarcinoma sample; somatic mutation)      0   0
strand         32   37
strand         40   46
strand         52   57
strand         73   75
strand         82   84
strand         93   95
strand         120   128
strand         154   164
strand         168   172
strand         176   182
strand         197   201
strand         205   209
strand         216   221
strand         226   231
strand         238   240
strand         243   246
strand         280   284
strand         286   288
strand         297   300
helix         100   104
helix         247   264
helix         273   279
active site   Proton acceptor   by similarity   688   688
splice variant   (in isoform 2)      0   0
splice variant   (in isoform 2)      71   977
binding site   ATP      599   599
nucleotide phosphate-binding region   ATP   by similarity   577   585
mutagenesis site   Loss of autophosphorylation and of endoribonuclease activity. Inhibition of growth arrest      0   0
mutagenesis site   No effect on dimerization. Weakens dimer; when associated with S-332      0   0
mutagenesis site   No effect on dimerization. Weakens dimer; when associated with S-148      0   0
mutagenesis site   No effect on dimerization      0   0
turn         47   49
turn         77   79
turn         211   213
turn         359   361

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MPARRLLLLLTLLLPGLG

Sequence

MPARRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTG
SIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGSKNNEGLTKLPFTI
PELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPS
TSLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYKMSHFVS
NGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKVMHINVAVETL
RYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMV
HEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDVKFDPGLKSKN
KLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSF
EEVINLVDQTSENAPTTVSRDVEEKPAHAPARPEAPVDSMLKDMATIILS
TFLLIGWVAFIITYPLSMHQQQQLQHQQFQKELEKIQLLQQQQQQLPFHP
PGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSGSSASKAGSSP
SLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKR
ILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQ
EYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPN
AHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKEN
PTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKH
EDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIE
KESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDL
LRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMEL
CSHERLFQPYYFHEPPEPQPPVTPDAL

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website