Signal Peptide Database

Signal Peptide Database - Mammalia

Entry Details

330

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

Q9ULV1 (Created: 2001-12-05 Updated: 2008-12-16)

UniProtKB/Swiss-Prot Entry Name

FZD4_HUMAN

Protein Name

Frizzled-4

Gene

FZD4

Organism Scientific

Homo sapiens

Organism Common

Human

Lineage

Eukaryota
  Metazoa
    Chordata
      Craniata
        Vertebrata
          Euteleostomi
            Mammalia
              Eutheria
                Euarchontoglires
                  Primates
                    Haplorrhini
                      Catarrhini
                        Hominidae
                          Homo

Protein Length [aa]

537

Protein Mass [Da]

59881

Features

TypeDescriptionStatusStartEnd
signal peptide      potential   1   36
chain   Frizzled-4      37   537
disulfide bond      by similarity   45   106
disulfide bond      by similarity   53   99
disulfide bond      by similarity   90   128
disulfide bond      by similarity   117   158
disulfide bond      by similarity   121   145
transmembrane region   1   potential   223   243
transmembrane region   2   potential   255   275
transmembrane region   3   potential   303   323
transmembrane region   4   potential   345   365
transmembrane region   5   potential   390   410
transmembrane region   6   potential   437   457
transmembrane region   7   potential   478   498
topological domain   Extracellular   potential   37   222
topological domain   Cytoplasmic   potential   244   254
topological domain   Extracellular   potential   276   302
topological domain   Cytoplasmic   potential   324   344
topological domain   Extracellular   potential   366   389
topological domain   Cytoplasmic   potential   411   436
topological domain   Extracellular   potential   458   477
topological domain   Cytoplasmic   potential   499   537
domain   FZ      40   161
glycosylation site   N-linked (GlcNAc...)   potential   59   59
glycosylation site   N-linked (GlcNAc...)   potential   144   144
sequence variant   (in EVR1; loss of function)      0   0
sequence variant   (in EVR1; loss of function)      0   0
sequence variant   (in a colorectal cancer sample; somatic mutation)      0   0
sequence variant   (in EVR1; loss of function)      493   494
short sequence motif   Lys-Thr-X-X-X-Trp motif      499   504
short sequence motif   PDZ-binding      535   537

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MAWRGAGPSVPGAPGGVGLSLGLLLQLLLLLGPARG

Sequence

MAWRGAGPSVPGAPGGVGLSLGLLLQLLLLLGPARGFGDEEERRCDPIRI
SMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCS
VYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPP
QNDHNHMCMEGPGDEEVPLPHKTPIQPGEECHSVGTNSDQYIWVKRSLNC
VLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSY
PERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNT
GCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIA
AWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLV
IGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPATC
VIACYFYEISNWALFRYSADDSNMAVEMLKIFMSLLVGITSGMWIWSAKT
LHTWQKCSNRLVNSGKVKREKRGNGWVKPGKGSETVV

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website