Signal Peptide Database

Signal Peptide Database - Mammalia

Entry Details

342

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

P06396 (Created: 1988-01-01 Updated: 2009-01-20)

UniProtKB/Swiss-Prot Entry Name

GELS_HUMAN

Protein Name

Gelsolin

Gene

GSN

Organism Scientific

Homo sapiens

Organism Common

Human

Lineage

Eukaryota
  Metazoa
    Chordata
      Craniata
        Vertebrata
          Euteleostomi
            Mammalia
              Eutheria
                Euarchontoglires
                  Primates
                    Haplorrhini
                      Catarrhini
                        Hominidae
                          Homo

Protein Length [aa]

782

Protein Mass [Da]

85698

Features

TypeDescriptionStatusStartEnd
signal peptide         1   27
chain   Gelsolin      28   782
disulfide bond   In isoform 1      215   228
region of interest   Actin-severing   potential   53   176
region of interest   Actin-actin interfilament contact point      123   126
region of interest   Polyphosphoinositide binding   by similarity   162   169
region of interest   Polyphosphoinositide binding   by similarity   188   196
region of interest   Actin-binding, Ca-sensitive   potential   434   782
modified residue   Phosphotyrosine; by SRC; in vitro      86   86
modified residue   Phosphotyrosine; by SRC; in vitro      409   409
modified residue   Phosphotyrosine; by SRC      465   465
modified residue   Phosphotyrosine; by SRC; in vitro      603   603
modified residue   Phosphotyrosine; by SRC; in vitro      651   651
sequence variant   (in dbSNP:rs2230287)      0   0
sequence variant   (in dbSNP:rs9696578)      0   0
sequence variant   (in a breast cancer sample; somatic mutation)      0   0
sequence variant   (in AMYL5)      0   0
sequence variant   (in AMYL5)      0   0
sequence variant   (in a breast cancer sample; somatic mutation)      0   0
sequence variant   (in a breast cancer sample; somatic mutation)      0   0
strand         64   74
strand         77   80
strand         88   90
strand         94   102
strand         108   116
strand         143   149
strand         166   169
strand         188   203
strand         214   219
strand         221   228
strand         256   262
strand         447   453
strand         456   459
strand         467   469
strand         472   482
strand         485   494
strand         521   527
strand         544   548
strand         562   570
strand         576   581
strand         592   597
strand         602   606
strand         630   633
strand         668   671
strand         697   702
strand         707   711
strand         744   748
strand         760   762
helix         57   61
helix         83   85
helix         122   138
helix         155   158
helix         207   209
helix         234   250
helix         268   274
helix         462   464
helix         500   516
helix         533   537
helix         585   587
helix         612   624
helix         639   644
helix         655   658
helix         690   692
helix         717   733
helix         754   757
repeat   Gelsolin-like 1      76   126
repeat   Gelsolin-like 2      198   238
repeat   Gelsolin-like 3      314   356
repeat   Gelsolin-like 4      453   504
repeat   Gelsolin-like 5      576   616
repeat   Gelsolin-like 6      679   721
splice variant   (in isoform 2)      1   51
turn         139   141
turn         517   519
turn         538   541
turn         553   555

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MAPHRPAPALLCALSLALCALSLPVRA

Sequence

MAPHRPAPALLCALSLALCALSLPVRAATASRGASQAGAPQGRVPEARPN
SMVVEHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKT
VQLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQ
GFESATFLGYFKSGLKYKKGGVASGFKHVVPNEVVVQRLFQVKGRRVVRA
TEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKATQVSKGIRDN
ERSGRARVHVSEEGTEPEAMLQVLGPKPALPAGTEDTAKEDAANRKLAKL
YKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQA
NTEERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPD
QTDGLGLSYLSSHIANVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIW
RIEGSNKVPVDPATYGQFYGGDSYIILYNYRHGGRQGQIIYNWQGAQSTQ
DEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGG
TSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPS
AAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAA
YRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVML
LDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVKQG
FEPPSFVGWFLGWDDDYWSVDPLDRAMAELAA

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website