Signal Peptide Database

Signal Peptide Database - Mammalia

Entry Details

364

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

Q8IWK6 (Created: 2004-07-19 Updated: 2008-12-16)

UniProtKB/Swiss-Prot Entry Name

GP125_HUMAN

Protein Name

Probable G-protein coupled receptor 125

Gene

GPR125

Organism Scientific

Homo sapiens

Organism Common

Human

Lineage

Eukaryota
  Metazoa
    Chordata
      Craniata
        Vertebrata
          Euteleostomi
            Mammalia
              Eutheria
                Euarchontoglires
                  Primates
                    Haplorrhini
                      Catarrhini
                        Hominidae
                          Homo

Protein Length [aa]

1321

Protein Mass [Da]

146151

Features

TypeDescriptionStatusStartEnd
signal peptide      potential   1   33
chain   Probable G-protein coupled receptor 125      34   1321
transmembrane region   1   potential   762   782
transmembrane region   2   potential   797   817
transmembrane region   3   potential   827   847
transmembrane region   4   potential   877   897
transmembrane region   5   potential   920   940
transmembrane region   6   potential   997   1017
transmembrane region   7   potential   1025   1045
topological domain   Extracellular   potential   34   761
topological domain   Cytoplasmic   potential   783   796
topological domain   Extracellular   potential   818   826
topological domain   Cytoplasmic   potential   848   876
topological domain   Extracellular   potential   898   919
topological domain   Cytoplasmic   potential   941   996
topological domain   Extracellular   potential   1018   1024
topological domain   Cytoplasmic   potential   1046   1321
domain   Ig-like      242   340
domain   GPS      698   749
modified residue   Phosphothreonine      208   208
glycosylation site   N-linked (GlcNAc...)   potential   81   81
glycosylation site   N-linked (GlcNAc...)   potential   98   98
glycosylation site   N-linked (GlcNAc...)   potential   159   159
glycosylation site   N-linked (GlcNAc...)   potential   206   206
glycosylation site   N-linked (GlcNAc...)   potential   301   301
glycosylation site   N-linked (GlcNAc...)   potential   332   332
glycosylation site   N-linked (GlcNAc...)   potential   433   433
glycosylation site   N-linked (GlcNAc...)   potential   453   453
glycosylation site   N-linked (GlcNAc...)   potential   592   592
glycosylation site   N-linked (GlcNAc...)   potential   652   652
glycosylation site   N-linked (GlcNAc...)   potential   687   687
glycosylation site   N-linked (GlcNAc...)   potential   728   728
glycosylation site   N-linked (GlcNAc...)   potential   821   821
sequence variant   (in dbSNP:rs9002)      0   0
sequence variant   (in dbSNP:rs3814416)      0   0
repeat   LRR 1      79   103
repeat   LRR 2      104   127
repeat   LRR 3      128   151
repeat   LRR 4      153   175
repeat   LRR 5      594   620
splice variant   (in isoform 4)      0   0
splice variant   (in isoform 2)      0   0
splice variant   (in isoform 4)      0   0
splice variant   (in isoform 3)      0   0
splice variant   (in isoform 4)      11   236
splice variant   (in isoform 3)      603   620
splice variant   (in isoform 4)      608   1321
splice variant   (in isoform 2)      617   1321
short sequence motif   PDZ-binding   potential   1319   1321

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MEPPGRRRGRAQPPLLLPLSLLALLALLGGGGG

Sequence

MEPPGRRRGRAQPPLLLPLSLLALLALLGGGGGGGAAALPAGCKHDGRPR
GAGRAAGAAEGKVVCSSLELAQVLPPDTLPNRTVTLILSNNKISELKNGS
FSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLNADIFR
GLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQTEYLLCDCNILWMHR
WVKEKNITVRDTRCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSH
RQVVFEGDSLPFQCMASYIDQDMQVLWYQDGRIVETDESQGIFVEKNMIH
NCSLIASALTISNIQAGSTGNWGCHVQTKRGNNTRTVDIVVLESSAQYCP
PERVVNNKGDFRWPRTLAGITAYLQCTRNTHGSGIYPGNPQDERKAWRRC
DRGGFWADDDYSRCQYANDVTRVLYMFNQMPLNLTNAVATARQLLAYTVE
AANFSDKMDVIFVAEMIEKFGRFTKEEKSKELGDVMVDIASNIMLADERV
LWLAQREAKACSRIVQCLQRIATYRLAGGAHVYSTYSPNIALEAYVIKST
GFTGMTCTVFQKVAASDRTGLSDYGRRDPEGNLDKQLSFKCNVSNTFSSL
ALKNTIVEASIQLPPSLFSPKQKRELRPTDDSLYKLQLIAFRNGKLFPAT
GNSTNLADDGKRRTVVTPVILTKIDGVNVDTHHIPVNVTLRRIAHGADAV
AARWDFDLLNGQGGWKSDGCHILYSDENITTIQCYSLSNYAVLMDLTGSE
LYTQAASLLHPVVYTTAIILLLCLLAVIVSYIYHHSLIRISLKSWHMLVN
LCFHIFLTCVVFVGGITQTRNASICQAVGIILHYSTLATVLWVGVTARNI
YKQVTKKAKRCQDPDEPPPPPRPMLRFYLIGGGIPIIVCGITAAANIKNY
GSRPNAPYCWMAWEPSLGAFYGPASFITFVNCMYFLSIFIQLKRHPERKY
ELKEPTEEQQRLAANENGEINHQDSMSLSLISTSALENEHTFHSQLLGAS
LTLLLYVALWMFGALAVSLYYPLDLVFSFVFGATSLSFSAFFVVHHCVNR
EDVRLAWIMTCCPGRSSYSVQVNVQPPNSNGTNGEAPKCPNSSAESSCTN
KSASSFKNSSQGCKLTNLQAAAAQCHANSLPLNSTPQLDNSLTEHSMDND
IKMHVAPLEVQFRTNVHSSRHHKNRSKGHRASRLTVLREYAYDVPTSVEG
SVQNGLPKSRLGNNEGHSRSRRAYLAYRERQYNPPQQDSSDACSTLPKSS
RNFEKPVSTTSKKDALRKPAVVELENQQKSYGLNLAIQNGPIKSNGQEGP
LLGTDSTGNVRTGLWKHETTV

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website