Signal Peptide Database

Signal Peptide Database - Mammalia

Entry Details

365

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

P07359 (Created: 1988-04-01 Updated: 2009-01-20)

UniProtKB/Swiss-Prot Entry Name

GP1BA_HUMAN

Protein Name

Platelet glycoprotein Ib alpha chain

Gene

GP1BA

Organism Scientific

Homo sapiens

Organism Common

Human

Lineage

Eukaryota
  Metazoa
    Chordata
      Craniata
        Vertebrata
          Euteleostomi
            Mammalia
              Eutheria
                Euarchontoglires
                  Primates
                    Haplorrhini
                      Catarrhini
                        Hominidae
                          Homo

Protein Length [aa]

626

Protein Mass [Da]

68955

Features

TypeDescriptionStatusStartEnd
signal peptide         1   16
chain   Platelet glycoprotein Ib alpha chain      17   626
chain   Glycocalicin      17   0
disulfide bond         20   33
disulfide bond         225   264
disulfide bond         227   280
transmembrane region      potential   506   526
topological domain   Extracellular   potential   17   505
topological domain   Cytoplasmic   potential   527   626
modified residue   Sulfotyrosine      292   292
modified residue   Phosphotyrosine      292   292
modified residue   Phosphotyrosine      294   294
modified residue   Sulfotyrosine      294   294
modified residue   Phosphotyrosine      295   295
modified residue   Sulfotyrosine      295   295
modified residue   Phosphoserine      603   603
modified residue   Phosphoserine      606   606
glycosylation site   N-linked (GlcNAc...)      37   37
glycosylation site   N-linked (GlcNAc...)      175   175
glycosylation site   O-linked (GalNAc...)      308   308
sequence variant   (in dbSNP:rs382524)      0   0
sequence variant   (in pseudo-vWD; increased binding to vWF)      0   0
sequence variant   (in BSS)      0   0
sequence variant   (in BSS)      0   0
sequence variant   (in Siba(+); dbSNP:rs6065)      0   0
sequence variant   (in pseudo-vWD)      0   0
sequence variant   (in pseudo-vWD)      0   0
sequence variant   (in BSS, benign mediterranean macrothrombocytopenia)      0   0
sequence variant   (in dbSNP:rs13306411)      0   0
sequence variant   (in BSS)      0   0
sequence variant   (in BSS)      0   0
sequence variant   (in dbSNP:rs6068)      0   0
sequence variant   (in BSS)      195   195
strand         19   23
strand         30   32
strand         51   53
strand         60   63
strand         75   77
strand         84   87
strand         97   99
strand         120   122
strand         144   146
strand         168   170
strand         192   194
strand         214   217
strand         262   264
strand         283   287
strand         579   587
helix         64   67
helix         227   229
helix         230   238
helix         240   242
helix         259   261
helix         272   274
repeat   LRR 1      70   92
repeat   LRR 2      93   117
repeat   LRR 3      119   138
repeat   LRR 4      139   162
repeat   LRR 5      164   186
repeat   LRR 6      188   210
compositionally biased region   Pro/Thr-rich      345   456
mutagenesis site   Decreased binding to vWF      0   0
mutagenesis site   Increased binding to vWF      0   0
mutagenesis site   No change      0   0
turn         112   114
turn         133   138
turn         157   162
turn         181   186
turn         205   210
turn         265   268

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MPLLLLLLLLPSPLHP

Sequence

MPLLLLLLLLPSPLHPHPICEVSKVASHLEVNCDKRNLTALPPDLPKDTT
ILHLSENLLYTFSLATLMPYTRLTQLNLDRCELTKLQVDGTLPVLGTLDL
SHNQLQSLPLLGQTLPALTVLDVSFNRLTSLPLGALRGLGELQELYLKGN
ELKTLPPGLLTPTPKLEKLSLANNNLTELPAGLLNGLENLDTLLLQENSL
YTIPKGFFGSHLLPFAFLHGNPWLCNCEILYFRRWLQDNAENVYVWKQGV
DVKAMTSNVASVQCDNSDKFPVYKYPGKGCPTLGDEGDTDLYDYYPEEDT
EGDKVRATRTVVKFPTKAHTTPWGLFYSWSTASLDSQMPSSLHPTQESTK
EQTTFPPRWTPNFTLHMESITFSKTPKSTTEPTPSPTTSEPVPEPAPNMT
TLEPTPSPTTPEPTSEPAPSPTTPEPTPIPTIATSPTILVSATSLITPKS
TFLTTTKPVSLLESTKKTIPELDQPPKLRGVLQGHLESSRNDPFLHPDFC
CLLPLGFYVLGLFWLLFASVVLILLLSWVGHVKPQALDSGQGAALTTATQ
TTHLELQRGRQVTVPRAWLLFLRGSLPTFRSSLFLWVRPNGRVGPLVAGR
RPSALSQGRGQDLLSTVSIRYSGHSL

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website