Signal Peptide Database

Signal Peptide Database - Mammalia

Entry Details

375

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

P42262 (Created: 1995-11-01 Updated: 2008-12-16)

UniProtKB/Swiss-Prot Entry Name

GRIA2_HUMAN

Protein Name

Glutamate receptor 2

Gene

GRIA2

Organism Scientific

Homo sapiens

Organism Common

Human

Lineage

Eukaryota
  Metazoa
    Chordata
      Craniata
        Vertebrata
          Euteleostomi
            Mammalia
              Eutheria
                Euarchontoglires
                  Primates
                    Haplorrhini
                      Catarrhini
                        Hominidae
                          Homo

Protein Length [aa]

883

Protein Mass [Da]

98821

Features

TypeDescriptionStatusStartEnd
signal peptide      potential   1   24
chain   Glutamate receptor 2      25   883
transmembrane region      potential   544   564
transmembrane region      potential   625   645
transmembrane region      potential   813   833
topological domain   Extracellular   potential   25   543
topological domain   Cytoplasmic   potential   565   624
topological domain   Extracellular   potential   646   812
topological domain   Cytoplasmic   potential   834   883
region of interest   Glutamate binding   by similarity   499   501
region of interest   Glutamate binding   by similarity   675   676
modified residue   Phosphoserine; by PKC   by similarity   683   683
modified residue   Phosphoserine; by PKG   by similarity   717   717
modified residue   Phosphotyrosine   by similarity   869   869
modified residue   Phosphotyrosine   by similarity   876   876
modified residue   Phosphoserine   by similarity   880   880
glycosylation site   N-linked (GlcNAc...)   potential   256   256
glycosylation site   N-linked (GlcNAc...)   potential   370   370
glycosylation site   N-linked (GlcNAc...)   potential   406   406
glycosylation site   N-linked (GlcNAc...)   potential   413   413
sequence variant   (in RNA edited version)      0   0
sequence variant   (in dbSNP:rs17850675)      0   0
splice variant   (in isoform Flip)      0   0
splice variant   (in isoform Flip)      0   0
splice variant   (in isoform Flip)      0   0
splice variant   (in isoform Flip)      0   0
splice variant   (in isoform 3)      0   0
binding site   Glutamate   by similarity   506   506
binding site   Glutamate   by similarity   726   726
lipid moiety-binding region   S-palmitoyl cysteine   by similarity   610   610
lipid moiety-binding region   S-palmitoyl cysteine   by similarity   836   836

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MQKIMHISVLLSPVLWGLIFGVSS

Sequence

MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQ
FSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTI
TSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAY
LYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQDLE
LKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKI
QFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALT
YDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQ
VQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLT
ELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLA
AEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPL
TITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCI
VFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWF
SLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERM
VSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEP
SVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDS
KGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGD
SKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAK
NAQNINPSSSQNSQNFATYKEGYNVYGIESVKI

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website