Signal Peptide Database

Signal Peptide Database - Mammalia

Entry Details

411

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

P05155 (Created: 1987-08-13 Updated: 2009-01-20)

UniProtKB/Swiss-Prot Entry Name

IC1_HUMAN

Protein Name

Plasma protease C1 inhibitor

Gene

SERPING1

Organism Scientific

Homo sapiens

Organism Common

Human

Lineage

Eukaryota
  Metazoa
    Chordata
      Craniata
        Vertebrata
          Euteleostomi
            Mammalia
              Eutheria
                Euarchontoglires
                  Primates
                    Haplorrhini
                      Catarrhini
                        Hominidae
                          Homo

Protein Length [aa]

500

Protein Mass [Da]

55154

Features

TypeDescriptionStatusStartEnd
signal peptide         1   22
chain   Plasma protease C1 inhibitor      23   500
disulfide bond         123   428
disulfide bond         130   205
region of interest   7 X 4 AA tandem repeats of [QE]-P-T-[TQ]      85   119
glycosylation site   N-linked (GlcNAc...)      25   25
glycosylation site   O-linked (GalNAc...)      48   48
glycosylation site   O-linked (GalNAc...)      64   64
glycosylation site   N-linked (GlcNAc...)      69   69
glycosylation site   O-linked (GalNAc...)      71   71
glycosylation site   N-linked (GlcNAc...)      81   81
glycosylation site   O-linked (GalNAc...)      83   83
glycosylation site   O-linked (GalNAc...)      88   88
glycosylation site   O-linked (GalNAc...)      92   92
glycosylation site   O-linked (GalNAc...)      96   96
glycosylation site   N-linked (GlcNAc...)      238   238
glycosylation site   N-linked (GlcNAc...)      253   253
glycosylation site   N-linked (GlcNAc...); in variant TA      272   272
glycosylation site   N-linked (GlcNAc...)      352   352
sequence variant   (in HAE; type 2)      0   0
sequence variant   (in HAE; type 2)      0   0
sequence variant   (in HAE; type 2)      0   0
sequence variant   (in HAE; type 2; MO)      0   0
sequence variant   (in HAE; type 2)      0   0
sequence variant   (in HAE; type 2)      0   0
sequence variant   (in HAE; type 2; AT)      0   0
sequence variant   (in HAE; type 2; DA; dbSNP:rs28940870)      0   0
sequence variant   (in HAE; type 1)      0   0
sequence variant   (in HAE; type 2)      0   0
sequence variant   (in HAE; type 2)      0   0
sequence variant   (in HAE; type 2)      0   0
sequence variant   (in dbSNP:rs4926)      0   0
sequence variant   (in HAE; type 2)      0   0
sequence variant   (in HAE; type 2)      0   0
sequence variant   (in HAE; type 2)      0   0
sequence variant   (in HAE; type 1)      0   0
sequence variant         0   0
sequence variant   (in HAE; type 1)      0   0
sequence variant   (in HAE; type 2; MA)      0   0
sequence variant   (in HAE; type 2; WE)      0   0
sequence variant   (in HAE; type 2)      0   0
sequence variant   (in HAE; type 1)      0   0
sequence variant   (in HAE; type 1)      0   0
sequence variant   (in HAE; type 1)      0   0
sequence variant   (in dbSNP:rs1803212)      0   0
sequence variant   (in dbSNP:rs11229062)      0   0
sequence variant   (in HAE; type 1)      0   0
sequence variant   (in dbSNP:rs11546660)      0   0
sequence variant   (in HAE; type 2)      84   138
sequence variant   (in HAE; type 2; TA; creates a new glycosylation site)      273   273
strand         167   169
strand         216   226
strand         287   301
strand         309   313
strand         320   337
strand         342   350
strand         353   362
strand         391   399
strand         402   408
strand         417   419
strand         441   449
strand         451   463
strand         468   470
strand         477   483
strand         488   495
helix         135   157
helix         171   183
helix         187   197
helix         206   211
helix         234   244
helix         255   268
helix         367   373
helix         376   387
helix         409   413
helix         414   416
helix         421   424
repeat   1      85   88
repeat   2      89   92
repeat   3      93   96
repeat   4      97   100
repeat   5      101   104
repeat   6      105   108
repeat   7      116   119
site   Reactive bond for chymotrypsin      465   466
site   Reactive bond      466   467
turn         269   272
turn         338   341
turn         428   430
turn         484   487

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MASRLTLLTLLLLLLAGDRASS

Sequence

MASRLTLLTLLLLLLAGDRASSNPNATSSSSQDPESLQDRGEGKVATTVI
SKMLFVEPILEVSSLPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTI
QPTQPTTQLPTDSPTQPTTGSFCPGPVTLCSDLESHSTEAVLGDALVDFS
LKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNLESILSYP
KDFTCVHQALKGFTTKGVTSVSQIFHSPDLAIRDTFVNASRTLYSSSPRV
LSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWK
TTFDPKKTRMEPFHFKNSVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLS
HNLSLVILVPQNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPR
IKVTTSQDMLSIMEKLEFFDFSYDLNLCGLTEDPDLQVSAMQHQTVLELT
ETGVEAAAASAISVARTLLVFEVQQPFLFVLWDQQHKFPVFMGRVYDPRA

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website