Signal Peptide Database

Signal Peptide Database - Mammalia

Entry Details

424

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

P29459 (Created: 1993-04-01 Updated: 2009-01-20)

UniProtKB/Swiss-Prot Entry Name

IL12A_HUMAN

Protein Name

Interleukin-12 subunit alpha

Gene

IL12A

Organism Scientific

Homo sapiens

Organism Common

Human

Lineage

Eukaryota
  Metazoa
    Chordata
      Craniata
        Vertebrata
          Euteleostomi
            Mammalia
              Eutheria
                Euarchontoglires
                  Primates
                    Haplorrhini
                      Catarrhini
                        Hominidae
                          Homo

Protein Length [aa]

219

Protein Mass [Da]

24874

Features

TypeDescriptionStatusStartEnd
signal peptide         1   22
chain   Interleukin-12 subunit alpha      23   219
disulfide bond         64   196
disulfide bond         85   123
disulfide bond   Interchain (with C-199 in IL12B)      96   96
glycosylation site   N-linked (GlcNAc...)   potential   93   93
glycosylation site   N-linked (GlcNAc...)   potential   107   107
helix         43   58
helix         59   61
helix         81   84
helix         88   92
helix         118   145
helix         155   169
helix         190   217

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MCPARSLLLVATLVLLDHLSLA

Sequence

MCPARSLLLVATLVLLDHLSLARNLPVATPDPGMFPCLHHSQNLLRAVSN
MLQKARQTLEFYPCTSEEIDHEDITKDKTSTVEACLPLELTKNESCLNSR
ETSFITNGSCLASRKTSFMMALCLSSIYEDLKMYQVEFKTMNAKLLMDPK
RQIFLDQNMLAVIDELMQALNFNSETVPQKSSLEEPDFYKTKIKLCILLH
AFRIRAVTIDRVMSYLNAS

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website