Signal Peptide Database

Signal Peptide Database - Mammalia

Entry Details

430

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

P16382 (Created: 1990-08-01 Updated: 2008-12-16)

UniProtKB/Swiss-Prot Entry Name

IL4RA_MOUSE

Protein Name

Interleukin-4 receptor alpha chain

Gene

Il4r

Organism Scientific

Mus musculus

Organism Common

Mouse

Lineage

Eukaryota
  Metazoa
    Chordata
      Craniata
        Vertebrata
          Euteleostomi
            Mammalia
              Eutheria
                Euarchontoglires
                  Glires
                    Rodentia
                      Sciurognathi
                        Muroidea
                          Muridae
                            Murinae
                              Mus

Protein Length [aa]

810

Protein Mass [Da]

87627

Features

TypeDescriptionStatusStartEnd
signal peptide         1   25
chain   Interleukin-4 receptor alpha chain      26   810
chain   Soluble interleukin-4 receptor alpha chain      26   0
disulfide bond      by similarity   34   44
disulfide bond      by similarity   75   87
transmembrane region      potential   234   257
topological domain   Extracellular   potential   26   233
topological domain   Cytoplasmic   potential   258   810
domain   Fibronectin type-III      124   220
region of interest   Required for IRS1 activation and IL4- induced cell growth   by similarity   441   557
region of interest   Required for IL4-induced gene expression   by similarity   557   653
modified residue   Phosphotyrosine      500   500
modified residue   Phosphotyrosine   probable   575   575
modified residue   Phosphotyrosine   probable   603   603
modified residue   Phosphotyrosine   probable   631   631
glycosylation site   N-linked (GlcNAc...)   potential   72   72
glycosylation site   N-linked (GlcNAc...)   potential   129   129
glycosylation site   N-linked (GlcNAc...)   potential   135   135
glycosylation site   N-linked (GlcNAc...)      163   163
sequence variant   (in strain: BALB/c, AKR/J, SJL/ J; reduced IL4-neutralizing capacity of soluble form)      0   0
sequence variant   (in strain: BALB/c, AKR/J, SJL/ J)      0   0
sequence variant   (in strain: BALB/c, AKR/J, SJL/ J)      0   0
sequence variant   (in strain: BALB/c, AKR/J, SJL/ J)      0   0
sequence variant   (in strain: BALB/c, AKR/J, SJL/ J)      0   0
sequence variant   (in strain: BALB/c, AKR/J, SJL/ J)      0   0
sequence variant   (in strain: BALB/c, AKR/J, SJL/ J)      0   0
sequence variant   (in strain: BALB/c, AKR/J, SJL/ J)      0   0
splice variant   (in isoform 2)      0   0
splice variant   (in isoform 2)      231   810
splice variant   (in isoform 3)      258   810
compositionally biased region   Poly-Glu      376   381
compositionally biased region   Poly-Glu      527   530
short sequence motif   WSXWS motif      213   217
short sequence motif   Box 1 motif      263   271
short sequence motif   ITIM motif      707   712

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MGRLCTKFLTSVGCLILLLVTGSGS

Sequence

MGRLCTKFLTSVGCLILLLVTGSGSIKVLGEPTCFSDYIRTSTCEWFLDS
AVDCSSQLCLHYRLMFFEFSENLTCIPRNSASTVCVCHMEMNRPVQSDRY
QMELWAEHRQLWQGSFSPSGNVKPLAPDNLTLHTNVSDEWLLTWNNLYPS
NNLLYKDLISMVNISREDNPAEFIVYNVTYKEPRLSFPINILMSGVYYTA
RVRVRSQILTGTWSEWSPSITWYNHFQLPLIQRLPLGVTISCLCIPLFCL
FCYFSITKIKKIWWDQIPTPARSPLVAIIIQDAQVPLWDKQTRSQESTKY
PHWKTCLDKLLPCLLKHRVKKKTDFPKAAPTKSLQSPGKAGWCPMEVSRT
VLWPENVSVSVVRCMELFEAPVQNVEEEEDEIVKEDLSMSPENSGGCGFQ
ESQADIMARLTENLFSDLLEAENGGLGQSALAESCSPLPSGSGQASVSWA
CLPMGPSEEATCQVTEQPSHPGPLSGSPAQSAPTLACTQVPLVLADNPAY
RSFSDCCSPAPNPGELAPEQQQADHLEEEEPPSPADPHSSGPPMQPVESW
EQILHMSVLQHGAAAGSTPAPAGGYQEFVQAVKQGAAQDPGVPGVRPSGD
PGYKAFSSLLSSNGIRGDTAAAGTDDGHGGYKPFQNPVPNQSPSSVPLFT
FGLDTELSPSPLNSDPPKSPPECLGLELGLKGGDWVKAPPPADQVPKPFG
DDLGFGIVYSSLTCHLCGHLKQHHSQEEGGQSPIVASPGCGCCYDDRSPS
LGSLSGALESCPEGIPPEANLMSAPKTPSNLSGEGKGPGHSPVPSQTTEV
PVGALGIAVS

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website