Signal Peptide Database

Signal Peptide Database - Viruses

Entry Details

2726

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

Q80S27 (Created: 2006-05-30 Updated: 2008-11-25)

UniProtKB/Swiss-Prot Entry Name

POLS_MIDDV

Protein Name

Structural polyprotein

Gene

Organism Scientific

Middelburg virus

Organism Common

Lineage

Viruses
  ssRNA positive-strand viruses, no DNA stage
    Togaviridae
      Alphavirus

Protein Length [aa]

1258

Protein Mass [Da]

138236

Features

TypeDescriptionStatusStartEnd
signal peptide   Not cleaved   potential   272   287
chain   Capsid protein   by similarity   1   271
chain   p62   by similarity   272   758
chain   E3 protein   by similarity   272   337
chain   E2 envelope glycoprotein   by similarity   338   758
chain   6K protein   by similarity   759   819
chain   E1 envelope glycoprotein   by similarity   820   1258
disulfide bond      by similarity   868   933
disulfide bond      by similarity   881   913
disulfide bond      by similarity   882   915
disulfide bond      by similarity   887   897
disulfide bond      by similarity   1078   1090
disulfide bond      by similarity   1120   1195
disulfide bond      by similarity   1125   1199
disulfide bond      by similarity   1147   1189
transmembrane region      potential   697   717
transmembrane region      potential   774   794
transmembrane region      potential   797   817
transmembrane region      potential   1235   1255
topological domain   Extracellular   potential   338   696
topological domain   Cytoplasmic   potential   718   758
topological domain   Extracellular   potential   759   773
topological domain   Cytoplasmic   potential   795   796
topological domain   Extracellular   potential   818   819
topological domain   Extracellular   potential   820   1234
topological domain   Cytoplasmic   potential   1256   1258
domain   Peptidase S3      116   271
region of interest   Intrinsically disordered, in contact with genomic RNA in nucleocapsid   potential   1   117
region of interest   Ribosome-binding   by similarity   100   110
region of interest   Transient transmembrane before p62-6K protein processing   potential   731   751
region of interest   E1 fusion peptide loop   by similarity   903   920
glycosylation site   N-linked (GlcNAc...)   potential   283   283
site   Cleavage; by capsid protein   by similarity   271   272
site   Cleavage; by host furin   by similarity   337   338
site   Cleavage; by host signal peptidase   by similarity   758   759
site   Cleavage; by host signal peptidase   by similarity   819   820
active site   Charge relay system   by similarity   149   149
active site   Charge relay system   by similarity   155   155
active site   Charge relay system   by similarity   223   223
lipid moiety-binding region   S-palmitoyl cysteine; by host   by similarity   731   731
lipid moiety-binding region   S-palmitoyl cysteine; by host   by similarity   751   751
lipid moiety-binding region   S-palmitoyl cysteine; by host   by similarity   752   752

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

TALVTTACILSNLTFD

Sequence

MNYIPTQTFYGRRWRPRPAARPWVAPPPVYYPPPPPVPVDPQAQQMQQLI
AAVNTLAIRQNGTRTPGQQRRKRQPNKPKRKQTPPKKQNPAKTKNKQKPQ
PPKPKKRKPGKRERKCMKIENDCIFEVKLEGKVTGYACLVGDKVMKPAHV
KGVIDNPDLAKLAFKKSSKYDLECAQIPVHMKSDASQFTHEKPEGHYNWH
HGAVQYLNGRFTIPTGAGKPGDSGRPIFDNKGRVVAIVLGGANEGARTAL
SVVTWNKDMVTRITPEGTEEWTALVTTACILSNLTFDCSLPPCAPCCYEK
DAEGTLRMLEDNVDNPGYYDLLAASTHCDAPQRRRRRGLTEDYKAYKLTK
PYIAYCSDCGNGQFCYSPIAIERVRAEASDGMLKIQISAQIGLQVDGAHS
WTKIRYMKGHDVEDTDRNSLEVFTTGECTVHGTMGHFIVATCPEGDSLTV
AFVDKHKVRHACRIAYKHRVPVLGREHFTVRPHHGVELPCTTYAMRTSVT
TEEIEMHVAHDVPDNTFLSKTGNKVKITPKGKSIRYNCTCGSKESGVTKQ
DKEFDNCEVSQCHTMVTAHDKWQFNSPYVPRAGSGKKGKIHVPFPLSNST
CRVPLAPLPNTIPAKNGITLQLHPVAPTLLTYRTLGEKPEHHTEWISESC
ERTLPVPEEGLEYTWGNHAPVRLWAQLTTKGSAHGMPHEIFSYYYGLYPA
TTVAVCVGLACVILLALSASCCLCVSARNKCLTPYALTPGAVVPCTLSLL
CCAPRAKAATFAETAAYLWAENQTVFWMQFAIPVACFMIVTYCLRHLMLC
CRTASFLVAVSLGMGATQAYEHSVTLPNAVGFPYRAHVDRPGFSPLTLHM
EVVSTSLEPTLALDYVTCEYKTVVPSPKVTCCGMSECAHQQKADFQCKVY
TGVYPFLWGGAYCFCDSENTQLSEAYVERSEVCKHDHAAAYRAHTAALKA
KISVTYGSTNGTAEAFVNGESTARIGDLKMILGPISTAWSPFDPKIVVYK
DEVYNQDYPPYGSGQPGRFGDLQSRTTESNDVYANTALKLARPSAGTVHV
PYTQTPSGFKYWLKEKGDALNHKAPFGCIIKTNPVRAENCAVGNIPVSLD
IPDAAFTRIVDAPSLTGLKCEVATCTHSSDFGGTLVVEYKTDKVGTCAVH
SESNTAVMQETSLSVTMDGRGTLHFSTASASPSFVLKVCSSKTTCTAKCV
PPKDHVVPFPANHNNVVFPDFSSTAVSWLTHTMGGATVVIAIGITIFLIV
TCIAFSRH

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website