Signal Peptide Database

Signal Peptide Database - Viruses

Entry Details

3285

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

P03375 (Created: 1986-07-21 Updated: 2008-11-25)

UniProtKB/Swiss-Prot Entry Name

ENV_HV1B1

Protein Name

Envelope glycoprotein gp160

Gene

env

Organism Scientific

Human immunodeficiency virus type 1 (isolate BH10 group M subtype B)

Organism Common

HIV-1

Lineage

Viruses
  Retro-transcribing viruses
    Retroviridae
      Orthoretrovirinae
        Lentivirus
          Primate lentivirus group

Protein Length [aa]

856

Protein Mass [Da]

97225

Features

TypeDescriptionStatusStartEnd
signal peptide      by similarity   1   32
chain   Envelope glycoprotein gp160      33   856
chain   Surface protein   by similarity   33   511
chain   Transmembrane protein   by similarity   512   856
disulfide bond         54   74
disulfide bond         119   205
disulfide bond         126   196
disulfide bond         131   157
disulfide bond         218   247
disulfide bond         228   239
disulfide bond         296   331
disulfide bond         378   445
disulfide bond         385   418
transmembrane region      potential   685   705
topological domain   Extracellular   potential   33   684
topological domain   Cytoplasmic   potential   706   856
region of interest   V1      131   156
region of interest   V2      157   196
region of interest   V3      296   330
region of interest   V4      385   418
region of interest   V5      461   471
region of interest   Fusion peptide   potential   512   532
region of interest   Immunosuppression   by similarity   576   592
region of interest   Involved in GalCer binding      662   667
glycosylation site   N-linked (GlcNAc...)      88   88
glycosylation site   N-linked (GlcNAc...)      136   136
glycosylation site   N-linked (GlcNAc...)      141   141
glycosylation site   N-linked (GlcNAc...)      156   156
glycosylation site   N-linked (GlcNAc...)      160   160
glycosylation site   N-linked (GlcNAc...)      186   186
glycosylation site   N-linked (GlcNAc...)      197   197
glycosylation site   N-linked (GlcNAc...)      230   230
glycosylation site   N-linked (GlcNAc...)      234   234
glycosylation site   N-linked (GlcNAc...)      241   241
glycosylation site   N-linked (GlcNAc...)      262   262
glycosylation site   N-linked (GlcNAc...)      276   276
glycosylation site   N-linked (GlcNAc...)      289   289
glycosylation site   N-linked (GlcNAc...)      295   295
glycosylation site   N-linked (GlcNAc...)      301   301
glycosylation site   N-linked (GlcNAc...)      332   332
glycosylation site   N-linked (GlcNAc...)      339   339
glycosylation site   N-linked (GlcNAc...)      356   356
glycosylation site   N-linked (GlcNAc...)      386   386
glycosylation site   N-linked (GlcNAc...)      392   392
glycosylation site   N-linked (GlcNAc...)      397   397
glycosylation site   N-linked (GlcNAc...)      406   406
glycosylation site   N-linked (GlcNAc...)      448   448
glycosylation site   N-linked (GlcNAc...)      463   463
glycosylation site   N-linked (GlcNAc...)   potential   611   611
glycosylation site   N-linked (GlcNAc...)   potential   616   616
glycosylation site   N-linked (GlcNAc...)   potential   625   625
glycosylation site   N-linked (GlcNAc...)   potential   637   637
glycosylation site   N-linked (GlcNAc...)   potential   674   674
sequence variant   (in strain: Isolate PV22)      0   0
sequence variant   (in strain: Isolate PV22)      0   0
sequence variant   (in strain: Isolate PV22)      0   0
sequence variant   (in strain: Isolate PV22)      0   0
sequence variant   (in strain: Isolate PV22)      0   0
sequence variant   (in strain: Isolate PV22)      0   0
sequence variant   (in strain: Isolate PV22)      0   0
sequence variant   (in strain: Isolate PV22)      0   0
site   Cleavage; by host furin   by similarity   511   512
short sequence motif   YXXL motif; contains endocytosis signal   by similarity   712   715
lipid moiety-binding region   S-palmitoyl cysteine; by host   by similarity   764   764
coiled-coil region      potential   542   592
coiled-coil region      potential   633   667

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MRVKEKYQHLWRWGWRWGTMLLGMLMICSATE

Sequence

MRVKEKYQHLWRWGWRWGTMLLGMLMICSATEKLWVTVYYGVPVWKEATT
TLFCASDAKAYDTEVHNVWATHACVPTDPNPQEVVLVNVTENFNMWKNDM
VEQMHEDIISLWDQSLKPCVKLTPLCVSLKCTDLKNDTNTNSSSGRMIME
KGEIKNCSFNISTSIRGKVQKEYAFFYKLDIIPIDNDTTSYTLTSCNTSV
ITQACPKVSFEPIPIHYCAPAGFAILKCNNKTFNGTGPCTNVSTVQCTHG
IRPVVSTQLLLNGSLAEEEVVIRSANFTDNAKTIIVQLNQSVEINCTRPN
NNTRKSIRIQRGPGRAFVTIGKIGNMRQAHCNISRAKWNNTLKQIDSKLR
EQFGNNKTIIFKQSSGGDPEIVTHSFNCGGEFFYCNSTQLFNSTWFNSTW
STKGSNNTEGSDTITLPCRIKQIINMWQEVGKAMYAPPISGQIRCSSNIT
GLLLTRDGGNSNNESEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTK
AKRRVVQREKRAVGIGALFLGFLGAAGSTMGAASMTLTVQARQLLSGIVQ
QQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQQLLGIWGCSG
KLICTTAVPWNASWSNKSLEQIWNNMTWMEWDREINNYTSLIHSLIEESQ
NQQEKNEQELLELDKWASLWNWFNITNWLWYIKLFIMIVGGLVGLRIVFA
VLSVVNRVRQGYSPLSFQTHLPIPRGPDRPEGIEEEGGERDRDRSIRLVN
GSLALIWDDLRSLCLFSYHRLRDLLLIVTRIVELLGRRGWEALKYWWNLL
QYWSQELKNSAVSLLNATAIAVAEGTDRVIEVVQGAYRAIRHIPRRIRQG
LERILL

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website