Signal Peptide Database

Signal Peptide Database - Viruses

Entry Details

3287

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

P03386 (Created: 1986-07-21 Updated: 2008-11-25)

UniProtKB/Swiss-Prot Entry Name

ENV_MLVAV

Protein Name

Envelope glycoprotein

Gene

env

Organism Scientific

AKV murine leukemia virus

Organism Common

AKR (endogenous) murine leukemia virus

Lineage

Viruses
  Retro-transcribing viruses
    Retroviridae
      Orthoretrovirinae
        Gammaretrovirus
          Murine leukemia virus

Protein Length [aa]

669

Protein Mass [Da]

73756

Features

TypeDescriptionStatusStartEnd
signal peptide      potential   1   31
chain   Envelope glycoprotein      32   669
chain   Surface protein   by similarity   32   470
chain   Transmembrane protein   by similarity   471   650
disulfide bond      by similarity   77   129
disulfide bond      by similarity   103   118
disulfide bond      by similarity   104   114
disulfide bond      by similarity   152   172
disulfide bond      by similarity   164   177
disulfide bond      by similarity   209   215
disulfide bond   Interchain (between SU and TM chains, or C-340 with C-564); alternate      337   564
disulfide bond   Alternate      337   340
disulfide bond      by similarity   367   421
disulfide bond      by similarity   386   398
disulfide bond      by similarity   428   441
disulfide bond      by similarity   556   563
transmembrane region      potential   612   632
topological domain   Extracellular   potential   1   611
topological domain   Cytoplasmic   potential   633   669
region of interest   Fusion peptide   by similarity   473   493
region of interest   Immunosuppression   by similarity   539   555
glycosylation site   N-linked (GlcNAc...)   by similarity   43   43
glycosylation site   N-linked (GlcNAc...)   by similarity   199   199
glycosylation site   N-linked (GlcNAc...)   potential   293   293
glycosylation site   N-linked (GlcNAc...)   by similarity   327   327
glycosylation site   N-linked (GlcNAc...)   potential   359   359
glycosylation site   N-linked (GlcNAc...)   potential   366   366
glycosylation site   N-linked (GlcNAc...)   potential   399   399
site   Cleavage; by host   by similarity   470   471
site   Cleavage; by viral protease   by similarity   650   651
metal ion-binding site   Zinc   by similarity   117   117
short sequence motif   CXXC      337   340
short sequence motif   CX6CC      556   564
short sequence motif   YXXL motif; contains endocytosis signal   by similarity   656   659
lipid moiety-binding region   S-palmitoyl cysteine; by host   by similarity   631   631
peptide   R-peptide (By similarity). /FTId=PRO_0000040747      651   669
coiled-coil region      potential   501   550
coiled-coil region      potential   560   596

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MESTTLSKPFKNQVNPWGPLIVLLILGGVNP

Sequence

MESTTLSKPFKNQVNPWGPLIVLLILGGVNPVTLGNSPHQVFNLTWEVTN
GDRETVWAITGNHPLWTWWPDLTPDLCMLALHGPSYWGLEYRAPFSPPPG
PPCCSGSSDSTPGCSRDCEEPLTSYTPRCNTAWNRLKLSKVTHAHNGGFY
VCPGPHRPRWARSCGGPESFYCASWGCETTGRASWKPSSSWDYITVSNNL
TSDQATPVCKGNEWCNSLTIRFTSFGKQATSWVTGHWWGLRLYVSGHDPG
LIFGIRLKITDSGPRVPIGPNPVLSDRRPPSRPRPTRSPPPSNSTPTETP
LTLPEPPPAGVENRLLNLVKGAYQALNLTSPDKTQECWLCLVSGPPYYEG
VAVLGTYSNHTSAPANCSVASQHKLTLSEVTGQGLCIGAVPKTHQVLCNT
TQKTSDGSYYLAAPTGTTWACSTGLTPCISTTILDLTTDYCVLVELWPRV
TYHSPSYVYHQFERRAKYKREPVSLTLALLLGGLTMGGIAAGVGTGTTAL
VATQQFQQLQAAMHDDLKEVEKSITNLEKSLTSLSEVVLQNRRGLDLLFL
KEGGLCAALKEECCFYADHTGLVRDSMAKLRERLSQRQKLFESQQGWFEG
LFNKSPWFTTLISTIMGPLIILLLILLFGPCILNRLVQFIKDRISVVQAL
VLTQQYHQLKTIEDCKSRE

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website