Signal Peptide Database

Signal Peptide Database - Viruses

Entry Details

3726

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

Q306W7 (Created: 2006-05-30 Updated: 2008-11-25)

UniProtKB/Swiss-Prot Entry Name

POLS_EEEV8

Protein Name

Structural polyprotein

Gene

Organism Scientific

Eastern equine encephalitis virus (strain PE-3.0815)

Organism Common

EEEV

Lineage

Viruses
  ssRNA positive-strand viruses, no DNA stage
    Togaviridae
      Alphavirus
        EEEV complex

Protein Length [aa]

1242

Protein Mass [Da]

137312

Features

TypeDescriptionStatusStartEnd
signal peptide   Not cleaved   potential   262   282
chain   Capsid protein   by similarity   1   261
chain   p62   by similarity   262   744
chain   E3 protein   by similarity   262   324
chain   E2 envelope glycoprotein   by similarity   325   744
chain   6K protein   by similarity   745   801
chain   E1 envelope glycoprotein   by similarity   802   1242
disulfide bond      by similarity   850   915
disulfide bond      by similarity   863   895
disulfide bond      by similarity   864   897
disulfide bond      by similarity   869   879
disulfide bond      by similarity   1061   1073
disulfide bond      by similarity   1103   1178
disulfide bond      by similarity   1108   1182
disulfide bond      by similarity   1130   1172
transmembrane region      potential   689   709
transmembrane region      potential   760   780
transmembrane region      potential   781   801
transmembrane region      potential   1219   1239
topological domain   Extracellular   potential   325   688
topological domain   Cytoplasmic   potential   710   744
topological domain   Extracellular   potential   745   759
topological domain   Extracellular   potential   802   1218
topological domain   Cytoplasmic   potential   1240   1242
domain   Peptidase S3      105   261
region of interest   Intrinsically disordered, in contact with genomic RNA in nucleocapsid   potential   7   106
region of interest   Ribosome-binding   by similarity   87   99
region of interest   Transient transmembrane before p62-6K protein processing   potential   717   737
region of interest   E1 fusion peptide loop   by similarity   885   902
glycosylation site   N-linked (GlcNAc...)   potential   272   272
site   Cleavage; by capsid protein   by similarity   261   262
site   Cleavage; by host furin   by similarity   324   325
site   Cleavage; by host signal peptidase   by similarity   744   745
site   Cleavage; by host signal peptidase   by similarity   801   802
active site   Charge relay system   by similarity   138   138
active site   Charge relay system   by similarity   144   144
active site   Charge relay system   by similarity   212   212
lipid moiety-binding region   S-palmitoyl cysteine; by host   by similarity   717   717
lipid moiety-binding region   S-palmitoyl cysteine; by host   by similarity   737   737
lipid moiety-binding region   S-palmitoyl cysteine; by host   by similarity   738   738

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

SLTTVMCVLANITFPCDQPPC

Sequence

MFPYPTLNYPPMAPVNPMAYRDPNPPRRRWRPFRPPLAAQIEDLRRSIAN
LTFKQRAPNPPAGPPAKRKKPAPKPKPAAPKKKRQPPPAKKQKRKQKPGK
RQRMCMKLESDKTFPIMLNGQVNGYACVVGGRVFKPLHVEGKIDNEQLAA
IKLKKASIYDLEYGDVPQCMKSDTLQYTSEKPPGFYNWHHGAVQYENNRF
TVPRGVGGKGDSGRPILDNRGRVVAIVLGGANEGSRTALSVVTWNQKGVT
VKDTPEGSEPWSLTTVMCVLANITFPCDQPPCMPCCYEKNPHETLSMLEQ
NYDSQAYDLLLDAAVKCNGRRTRRDLETHFTQYKLARPYIADCSNCGHGR
CDSPIAIEDIRGDAHAGYIRIQTSAMFGLKSDGVDLAYMSFMNGKTLKAI
KIEHLYARTSAPCSLVSYHGYYILAQCPPGDTVTVGFQDGAIKHMCTIAH
KVEFKPVGREKYRHPPEHGVELPCTKYTHKRADQGHYVEMHQPGLVADHS
LLSMSSTKVKITVPSGSQVKYYCKCPDVKEGTTGSDYTTACTDLKQCRAY
LIDNKKWVYNSGKLPRGEGETFKGKLHVPFVPVTSKCTATLAPEPLVEHK
HRSLVLHLHPEHPTLLTTRALGSNARPTRQWIEQPTTVNFTVTGEGFEYT
WGNHPPKRVWAQESGEGNPHGWPHEIVIYYYNRYPMTTVIGLCTCVAIIM
VSCVTSVWLLCRTRNLCITPYRLAPNAQVPILLAVLCCVKPTRADDTLQV
LNYLWNNNQNFFWMQTLIPLAALIVCMRMLRCLLCCGPAFLLVCGALGAA
AYEHAAVMPNKVGIPYKALVERPGYAPVHLQIQLVTTKIIPSANLEYITC
KYKTKVPSPVVKCCGSTQCSAKSLPDYQCQVFTGVYPFMWGGAYCFCDTE
NTQMSEVYIERAEECSVDQAKAYKVHTGTVQAVVNITYGSVSWRSADVYV
NGETPAKIGDAKLTIGPLSSAWSPFDSKVVVYGHEVYNYDFPEYGTGKAG
SFGDLQSRTLTSNDLYANTNLKLQRPQPGVVHTPYTQAPSGFERWKKDRG
APLNDIAPFGCTIALDPLRAENCAVGNIPLSIDIPDAAFTRIAETPTVSD
LECKVTECTYASDFGGIATISYKASKAGNCPIHSPSGIAVIKENDVTLAD
SGAFTFHFSTASIHPAFKMQVCTSVVTCKGDCKPPKDHIVDYPAQHTETY
TSAVSATAWSWLKVLVGSTSAFIVLGLIATAVVALVLFTHRH

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website