Signal Peptide Database

Signal Peptide Database - Viruses

Entry Details

4290

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

Q9QBZ0 (Created: 2006-06-27 Updated: 2008-11-25)

UniProtKB/Swiss-Prot Entry Name

ENV_HV1M2

Protein Name

Envelope glycoprotein gp160

Gene

env

Organism Scientific

Human immunodeficiency virus type 1 (isolate MP257 group M subtype F2)

Organism Common

HIV-1

Lineage

Viruses
  Retro-transcribing viruses
    Retroviridae
      Orthoretrovirinae
        Lentivirus
          Primate lentivirus group

Protein Length [aa]

850

Protein Mass [Da]

96359

Features

TypeDescriptionStatusStartEnd
signal peptide      by similarity   1   31
chain   Envelope glycoprotein gp160   by similarity   32   850
chain   Surface protein   by similarity   32   505
chain   Transmembrane protein   by similarity   506   850
disulfide bond      by similarity   53   73
disulfide bond      by similarity   118   206
disulfide bond      by similarity   125   197
disulfide bond      by similarity   130   158
disulfide bond      by similarity   219   248
disulfide bond      by similarity   229   240
disulfide bond      by similarity   297   331
disulfide bond      by similarity   376   440
disulfide bond      by similarity   383   413
transmembrane region      potential   679   699
topological domain   Extracellular   potential   32   678
topological domain   Cytoplasmic   potential   700   850
region of interest   V1      130   157
region of interest   V2      158   197
region of interest   V3      297   330
region of interest   V4      383   413
region of interest   V5      456   465
region of interest   Fusion peptide   potential   506   526
region of interest   Immunosuppression   by similarity   570   586
region of interest   Involved in GalCer binding   by similarity   656   661
glycosylation site   N-linked (GlcNAc...)   potential   87   87
glycosylation site   N-linked (GlcNAc...)   potential   129   129
glycosylation site   N-linked (GlcNAc...)   potential   136   136
glycosylation site   N-linked (GlcNAc...)   potential   141   141
glycosylation site   N-linked (GlcNAc...)   potential   142   142
glycosylation site   N-linked (GlcNAc...)   potential   148   148
glycosylation site   N-linked (GlcNAc...)   potential   157   157
glycosylation site   N-linked (GlcNAc...)   potential   161   161
glycosylation site   N-linked (GlcNAc...)   potential   186   186
glycosylation site   N-linked (GlcNAc...)   potential   189   189
glycosylation site   N-linked (GlcNAc...)   potential   198   198
glycosylation site   N-linked (GlcNAc...)   potential   231   231
glycosylation site   N-linked (GlcNAc...)   potential   235   235
glycosylation site   N-linked (GlcNAc...)   potential   242   242
glycosylation site   N-linked (GlcNAc...)   potential   263   263
glycosylation site   N-linked (GlcNAc...)   potential   277   277
glycosylation site   N-linked (GlcNAc...)   potential   296   296
glycosylation site   N-linked (GlcNAc...)   potential   302   302
glycosylation site   N-linked (GlcNAc...)   potential   332   332
glycosylation site   N-linked (GlcNAc...)   potential   354   354
glycosylation site   N-linked (GlcNAc...)   potential   384   384
glycosylation site   N-linked (GlcNAc...)   potential   390   390
glycosylation site   N-linked (GlcNAc...)   potential   401   401
glycosylation site   N-linked (GlcNAc...)   potential   406   406
glycosylation site   N-linked (GlcNAc...)   potential   443   443
glycosylation site   N-linked (GlcNAc...)   potential   457   457
glycosylation site   N-linked (GlcNAc...)   potential   605   605
glycosylation site   N-linked (GlcNAc...)   potential   610   610
glycosylation site   N-linked (GlcNAc...)   potential   619   619
glycosylation site   N-linked (GlcNAc...)   potential   631   631
site   Cleavage; by host furin   by similarity   505   506
short sequence motif   YXXL motif; contains endocytosis signal   by similarity   706   709
lipid moiety-binding region   S-palmitoyl cysteine; by host   by similarity   758   758
coiled-coil region      potential   536   586
coiled-coil region      potential   627   661

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MRVREMQRNWQHLGRWGLLFLGILIICSAAD

Sequence

MRVREMQRNWQHLGRWGLLFLGILIICSAADKLWVTVYYGVPVWKEATTT
LFCASDAKAYEREVHNVWATYACVPTDPSPQELVLGNVSEKFNMWKNNMV
DQMHEDIISLWDESLKPCVKLTPLCVTLNCTKAIINVTSSNNTTLAPNVT
ISEEMKNCSFNITTEIRDKQKKEYALFYKLDVVQINNSNTSYRLINCNTS
TLTQACPKVSFDPIPIHYCAPAGFAILKCNNKTFNGTGLCRNVSTVQCTH
GIKPVVSTQLLLNGSLAEEKMIIRSENISDNTKTIIVQFKNPVKINCTRP
NNNTRRSIHIGPGRAFYATGEIIGDTRKAHCNISEKQWYDTLIKIATEFK
DQYNKTVGFQPSAGGDLEITTHSFNCRGEFFYCNTTILFNHTRVNDILSN
NHTRENDTITLPCRIKQIVNMWQRVGQAMYAPPIAGKIQCNSNITGLLLT
IDGGEGNESETLRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTKAKRQVV
QREKRAVGMGAMFLGFLGAAGSTMGAASITLTVQARNLLSGIVQQQSNLL
KAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQQLLGIWGCSGKLICPT
TVPWNLSWSNKSQDEIWGNMTWMEWEKEIGNYTDTIYRLIESAQNQQEKN
EQDLLALDKWDNLWNWFSITRWLWYIEIFIMIIGSLIGLRIVFTVLSIIN
RVRQGYSPLSLQTLIPNSRGPERPGGIEEEGGEQDKDRSIRLVSGFLALA
WDDFRSLCVFSYHCLRNFILIAARTVDKGLKRGWEVLKYLWNLAQYWGQE
LKNSAISLLDRTAIAVAEGTDRIIEILQRAGRAVLNIPRRIRQGLERALL

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website