Signal Peptide Database

Signal Peptide Database - Viruses

Entry Details

5307

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

P03378 (Created: 1986-07-21 Updated: 2008-11-25)

UniProtKB/Swiss-Prot Entry Name

ENV_HV1A2

Protein Name

Envelope glycoprotein gp160

Gene

env

Organism Scientific

Human immunodeficiency virus type 1 (isolate ARV2/SF2 group M subtype B)

Organism Common

HIV-1

Lineage

Viruses
  Retro-transcribing viruses
    Retroviridae
      Orthoretrovirinae
        Lentivirus
          Primate lentivirus group

Protein Length [aa]

855

Protein Mass [Da]

97438

Features

TypeDescriptionStatusStartEnd
signal peptide      by similarity   1   31
chain   Envelope glycoprotein gp160      32   855
chain   Surface protein   by similarity   32   509
chain   Transmembrane protein   by similarity   510   855
disulfide bond      by similarity   53   73
disulfide bond      by similarity   118   208
disulfide bond      by similarity   125   199
disulfide bond      by similarity   130   155
disulfide bond      by similarity   221   250
disulfide bond      by similarity   231   242
disulfide bond      by similarity   299   333
disulfide bond      by similarity   380   442
disulfide bond      by similarity   387   415
transmembrane region      potential   684   704
topological domain   Extracellular   potential   32   683
topological domain   Cytoplasmic   potential   705   855
region of interest   V1      130   154
region of interest   V2      155   199
region of interest   V3      299   332
region of interest   V4      387   415
region of interest   V5      458   469
region of interest   Fusion peptide   potential   510   530
region of interest   Immunosuppression   by similarity   575   591
region of interest   Involved in GalCer binding   by similarity   661   666
glycosylation site   N-linked (GlcNAc...)   potential   87   87
glycosylation site   N-linked (GlcNAc...)   potential   129   129
glycosylation site   N-linked (GlcNAc...)   potential   140   140
glycosylation site   N-linked (GlcNAc...)   potential   154   154
glycosylation site   N-linked (GlcNAc...)   potential   158   158
glycosylation site   N-linked (GlcNAc...)   potential   184   184
glycosylation site   N-linked (GlcNAc...)   potential   190   190
glycosylation site   N-linked (GlcNAc...)   potential   200   200
glycosylation site   N-linked (GlcNAc...)   potential   233   233
glycosylation site   N-linked (GlcNAc...)   potential   244   244
glycosylation site   N-linked (GlcNAc...)   potential   265   265
glycosylation site   N-linked (GlcNAc...)   potential   279   279
glycosylation site   N-linked (GlcNAc...)   potential   292   292
glycosylation site   N-linked (GlcNAc...)   potential   298   298
glycosylation site   N-linked (GlcNAc...)   potential   304   304
glycosylation site   N-linked (GlcNAc...)   potential   334   334
glycosylation site   N-linked (GlcNAc...)   potential   341   341
glycosylation site   N-linked (GlcNAc...)   potential   358   358
glycosylation site   N-linked (GlcNAc...)   potential   364   364
glycosylation site   N-linked (GlcNAc...)   potential   388   388
glycosylation site   N-linked (GlcNAc...)   potential   394   394
glycosylation site   N-linked (GlcNAc...)   potential   400   400
glycosylation site   N-linked (GlcNAc...)   potential   408   408
glycosylation site   N-linked (GlcNAc...)   potential   445   445
glycosylation site   N-linked (GlcNAc...)   potential   458   458
glycosylation site   N-linked (GlcNAc...)   potential   461   461
glycosylation site   N-linked (GlcNAc...)   potential   610   610
glycosylation site   N-linked (GlcNAc...)   potential   615   615
glycosylation site   N-linked (GlcNAc...)   potential   624   624
glycosylation site   N-linked (GlcNAc...)   potential   636   636
site   Cleavage; by host furin   by similarity   509   510
short sequence motif   YXXL motif; contains endocytosis signal   by similarity   711   714
lipid moiety-binding region   S-palmitoyl cysteine; by host   by similarity   763   763
coiled-coil region      potential   541   591
coiled-coil region      potential   632   666

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MKVKGTRRNYQHLWRWGTLLLGMLMICSATE

Sequence

MKVKGTRRNYQHLWRWGTLLLGMLMICSATEKLWVTVYYGVPVWKEATTT
LFCASDARAYDTEVHNVWATHACVPTDPNPQEVVLGNVTENFNMWKNNMV
EQMQEDIISLWDQSLKPCVKLTPLCVTLNCTDLGKATNTNSSNWKEEIKG
EIKNCSFNITTSIRDKIQKENALFRNLDVVPIDNASTTTNYTNYRLIHCN
RSVITQACPKVSFEPIPIHYCTPAGFAILKCNNKTFNGKGPCTNVSTVQC
THGIRPIVSTQLLLNGSLAEEEVVIRSDNFTNNAKTIIVQLNESVAINCT
RPNNNTRKSIYIGPGRAFHTTGRIIGDIRKAHCNISRAQWNNTLEQIVKK
LREQFGNNKTIVFNQSSGGDPEIVMHSFNCRGEFFYCNTTQLFNNTWRLN
HTEGTKGNDTIILPCRIKQIINMWQEVGKAMYAPPIGGQISCSSNITGLL
LTRDGGTNVTNDTEVFRPGGGDMRDNWRSELYKYKVIKIEPLGIAPTKAK
RRVVQREKRAVGIVGAMFLGFLGAAGSTMGAVSLTLTVQARQLLSGIVQQ
QNNLLRAIEAQQHLLQLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGK
LICTTAVPWNASWSNKSLEDIWDNMTWMQWEREIDNYTNTIYTLLEESQN
QQEKNEQELLELDKWASLWNWFSITNWLWYIKIFIMIVGGLVGLRIVFAV
LSIVNRVRQGYSPLSFQTRLPVPRGPDRPDGIEEEGGERDRDRSVRLVDG
FLALIWEDLRSLCLFSYRRLRDLLLIAARTVEILGHRGWEALKYWWSLLQ
YWIQELKNSAVSWLNATAIAVTEGTDRVIEVAQRAYRAILHIHRRIRQGL
ERLLL

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website